{"product_id":"revvity-net1051250uc","title":"Revvity, NET1051250UC, CP 55940, [Side Chain-2,3,4- H(N)]-, 250µCi (9.25MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\n250 µCi quantity of CP 55940, [Side Chain-2,3,4-3H(N)]-, is available for your research.\u003cbr\u003e\nCP 55,940 is a synthetic cannabinoid that mimics the effects of naturally occuring tetrahydrocannabinol (THC). It acts as a full agonist at cannabinoid receptors type 1 and 2. These GPCRs are potential drug targets for a variety of diseases, including epilepsy, cancer, obesity, and osteoporosis.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET1051:\u003c\/p\u003e\n\n\u003cp\u003eChiang, Y.-C. and Chen, J.-C. (2007), The role of the cannabinoid type 1 receptor and down-stream cAMP\/DARPP-32 signal in the nucleus accumbens of methamphetamine-sensitized rats. Journal of Neurochemistry, 103: 2505–2517.\u003cbr\u003e\nGatch MB, Kozlenkov A, Huang RQ, Yang W, Nguyen JD, González-Maeso J, et al. (2013), The HIV antiretroviral drug efavirenz has LSD-like properties. Neuropsychopharmacology, 38: 2373–2384. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-376\u003cbr\u003e\nSpecific Activity-100 - 180 Ci\/mmol (3700 - 6660 GBq\/mmol)\u003cbr\u003e\nCAS Number-83002-04-4\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Nominally Labeled\u003cbr\u003e\nMolecular Formula-C24H40O3\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Cannabinoid\u003cbr\u003e\nShipping Information-Shipped in Dry Ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-Angiogenesis Cardiovascular CNS \u0026amp; Neurologic Gastrointestinal Inflammation Metabolic Disorders Pain\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775198744745,"sku":"NET1051250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net1051250uc","provider":"Iright","version":"1.0","type":"link"}