{"product_id":"revvity-net1153250uc","title":"Revvity, NET1153250UC, RX 821002, [6,7-3H(N)]-","description":"\u003cp\u003eOverview\u003cbr\u003e\nRX 821002 acts as an antagonist at α2-adrenoceptors. These receptors belong to a group of GPCRs that are potential drug targets for hypertension and opiate addiction.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET1153:\u003c\/p\u003e\n\n\u003cp\u003eStaffan Uhlén, Helgi B. Schiöth, Jan Anker Jahnsen, A new, simple and robust radioligand binding method used to determine kinetic off-rate constants for unlabeled ligands. Application at α2A- and α2C-adrenoceptors, European Journal of Pharmacology, Volume 788, 2016, Pages 113-121.\u003cbr\u003e\nJan Anker Jahnsen, Staffan Uhlén, The predicted N-terminal signal sequence of the human α2C-adrenoceptor does not act as a functional cleavable signal peptide, European Journal of Pharmacology, Volume 684, Issues 1–3, 2012, Pages 51-58. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-234.25\u003cbr\u003e\nSpecific Activity-\u0026gt;30 Ci\/mmol (\u0026gt;1110 GBq\/mmol)\u003cbr\u003e\nCAS Number-102575-24-6\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol : 0.05N hydrochloric acid (1:9)\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C12H14N2O3\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Adrenoceptors\u003cbr\u003e\nShipping Information-Blue Ice\u003cbr\u003e\nShipping Conditions-Shipped in Blue Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions-5°C\u003cbr\u003e\nTherapeutic Area-Cardiovascular Gastrointestinal\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775385096361,"sku":"NET1153250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net1153250uc","provider":"Iright","version":"1.0","type":"link"}