{"product_id":"revvity-net1158250uc","title":"Revvity, NET1158250UC, SR141716A, [ H]","description":"\u003cp\u003eOverview\u003cbr\u003e\nSR141716A acts as an antagonist at the cannabinoid CB1 receptor, and is used to treat obesity. Cannabinoid receptors are a group of GPCRs that are potential drug targets for smoking sessation and weight loss.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET1158:\u003c\/p\u003e\n\n\u003cp\u003eBisset, K.M., Dhopeshwarkar, A.S., Liao, C., Nicholson, R.A. (2011) The G protein-coupled cannabinoid-1 (CB1) receptor of mammalian brain: Inhibition by phthalate esters in vitro, Neurochemistry International, 59 (5): 706-713.\u003cbr\u003e\nLiao, C., Zheng, J., David, L. S. and Nicholson, R. A. (2004), Inhibition of Voltage-Sensitive Sodium Channels by the Cannabinoid 1 Receptor Antagonist AM 251 in Mammalian Brain. Basic \u0026amp; Clinical Pharmacology \u0026amp; Toxicology, 94: 73–78. Concentration-0.2 mCi\/ml\u003cbr\u003e\nMolecular Weight-463.79\u003cbr\u003e\nSpecific Activity-35 - 60 Ci\/mmol (1295 - 2220 GBq\/mmol)\u003cbr\u003e\nCAS Number-158681-13-1\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C22H21Cl3N4O\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Cannabinoid\u003cbr\u003e\nShipping Information-Dry Ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-Angiogenesis Cardiovascular CNS \u0026amp; Neurologic Gastrointestinal Inflammation Metabolic Disorders Pain\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775392960681,"sku":"NET1158250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net1158250uc","provider":"Iright","version":"1.0","type":"link"}