{"product_id":"revvity-net1172u100uc","title":"Revvity, NET1172U100UC, GR125743, [N-methyl- H], 100 µCi","description":"\u003cp\u003eOverview\u003cbr\u003e\nGR125743 acts as an antagonist at serotonin 5-HT1B and 5-HT1D receptors. These receptors belong to a class of serotonin GPCRs and are potential drug targets for depression and anxiety.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET1172:\u003c\/p\u003e\n\n\u003cp\u003eGolnasim Riahi, Marc Morissette, Pershia Samadi, Martin Parent, Thérèse Di Paolo, Basal ganglia serotonin 1B receptors in parkinsonian monkeys with L-DOPA-induced dyskinesia, In Biochemical Pharmacology, Volume 86, Issue 7, 2013, Pages 970-978. Concentration-0.1 mCi\/mL\u003cbr\u003e\nMolecular Weight-416.5\u003cbr\u003e\nSpecific Activity-50 - 86 Ci\/mmol (1850 - 3182 GBq\/mmol)\u003cbr\u003e\nCAS Number-148547-33-5\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C25H28N4O2\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-5-Hydroxytryptamine\u003cbr\u003e\nShipping Information-Dry Ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic\u003cbr\u003e\nUnit Size-100 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775215816873,"sku":"NET1172U100UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net1172u100uc","provider":"Iright","version":"1.0","type":"link"}