{"product_id":"revvity-net131001mc","title":"Revvity, NET131001MC, Dihydroxyphenylethylamine, 3,4-[7- H]-, 1mCi (37MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\n1 mCi quantity of Dihydroxyphenylethylamine, 3,4-[7-3H]-, is available for your research. Dihydroxyphenylethylamine binds dopamine receptors, a class of GPCRs in the central nervous system. Dopamine receptors are implicated in motivation, pleasure, cognition, memory, and learning and are potential drug targets for schizophrenia, Parkinson's disease, and a variety of other psychiatric and neurological conditions.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET131:\u003c\/p\u003e\n\n\u003cp\u003eOaks AW, Frankfurt M, Finkelstein DI, Sidhu A (2013) Age-Dependent Effects of A53T Alpha-Synuclein on Behavior and Dopaminergic Function. PLoS ONE 8(4): e60378.\u003cbr\u003e\nOaks AW, Marsh-Armstrong N, Jones JM, Credle JJ, Sidhu A (2013) Synucleins Antagonize Endoplasmic Reticulum Function to Modulate Dopamine Transporter Trafficking. PLoS ONE 8(8): e70872. Concentration-1 mCi\/mL\u003cbr\u003e\nMolecular Weight-153.2\u003cbr\u003e\nSpecific Activity-20 - 40 Ci\/mmol (740 - 1480 GBq\/mmol)\u003cbr\u003e\nCAS Number-62-31-7\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-0.2N acetic acid : ethanol (9:1)\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C8H11NO2\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Dopamine\u003cbr\u003e\nShipping Information-Shipped in Dry Ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions-5°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic\u003cbr\u003e\nUnit Size-1 mCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775205691561,"sku":"NET131001MC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net131001mc","provider":"Iright","version":"1.0","type":"link"}