{"product_id":"revvity-net377250uc","title":"Revvity, NET377250UC, Norepinephrine, Levo-[7- H]-, 250µCi (9.25MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\n250 µCi quantities of Norepinephrine, Levo-[7-3H]-, is available for your research. Norepinephrine (NA) is a neurotransmitter and hormone that increases heart rate and blood pressure, and is involved in the fight-or-flight response. It is widely used to treat low blood pressure.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET377:\u003c\/p\u003e\n\n\u003cp\u003eJeannotte, A. M. and Sidhu, A. (2007), Regulation of the norepinephrine transporter by α-synuclein-mediated interactions with microtubules. European Journal of Neuroscience, 26: 1509–1520.\u003cbr\u003e\nWersinger, C., Jeannotte, A. and Sidhu, A. (2006), Attenuation of the norepinephrine transporter activity and trafficking via interactions with α-synuclein. European Journal of Neuroscience, 24: 3141–3152. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-169.2\u003cbr\u003e\nSpecific Activity-\u0026gt;8 Ci\/mmol (\u0026gt;296 GBq\/mmol)\u003cbr\u003e\nCAS Number-51-41-2\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-0.2N acetic acid : ethanol (9:1)\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Nominally Labeled\u003cbr\u003e\nMolecular Formula-C8H11NO3\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Adrenoceptors\u003cbr\u003e\nShipping Information-Shipped in Dry Ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--80°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775360585897,"sku":"NET377250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net377250uc","provider":"Iright","version":"1.0","type":"link"}