{"product_id":"revvity-net567250uc","title":"Revvity, NET567250UC, Flunitrazepam, [Methyl- H]-, 250µCi (9.25MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\nFlunitrazepam acts as an agonist at GABAA receptors. This receptor is an aionotropic receptor and ligand-gated ion channel. Flunitrazepam is used to treat severe insomnia and has also been used as an anesthetic.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET567:\u003c\/p\u003e\n\n\u003cp\u003eM. Rey, A.S. Veleiro, A.A. Ghini, M.S. Kruse, G. Burton, H. Coirini, Effect of synthetic steroids on GABAA receptor binding in rat brain, In Neuroscience, Volume 290, 2015, Pages 138-146.\u003cbr\u003e\nMariana Rey, María Sol Kruse, Lautaro D. Alvarez, Alberto A. Ghini, Adriana S. Veleiro, Gerardo Burton, Héctor Coirini, Neuroprotective action of synthetic steroids with oxygen bridge. Activity on GABAA receptor, In Experimental Neurology, Volume 249, 2013, Pages 49-58. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-313.3\u003cbr\u003e\nSpecific Activity-70 - 87 Ci\/mmol (2590 - 3219 GBq\/mmol)\u003cbr\u003e\nCAS Number-1622-62-4\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C16H12FN3O3\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Benzodiazepine GABAA\u003cbr\u003e\nShipping Information-Shipped Ambient\u003cbr\u003e\nShipping Conditions-Shipped Ambient\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775212507305,"sku":"NET567250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net567250uc","provider":"Iright","version":"1.0","type":"link"}