{"product_id":"revvity-net574250uc","title":"Revvity, NET574250UC, Muscimol, 3-Hydroxy-5-Aminomethylisoxazole, [Methylene- H(N)]-, 250µCi (9.25MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\nMuscimol function as a potent selective agonist at GABAAreceptors. It binds to the same site on these receptors as GABA itself. Muscimol has minimal affinity for GABA uptake sites making it more attractive for receptor studies than GABA itself. It also acts as a partial agonist at GABAA-rho receptor. Muscimol is classified as an isoxazole; it displays sedatives-hypnotic, depressant and dissociative psychoactivity. When administered, it affects neuronal activity in multiple regions of the brain including the cerebral cortex, hippocampus and cerebellum.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET574:\u003c\/p\u003e\n\n\u003cp\u003eM. Rey, A.S. Veleiro, A.A. Ghini, M.S. Kruse, G. Burton, H. Coirini. Effect of synthetic steroids on GABAA receptor binding in rat brain. Neuroscience. April 2015. Volume 290, pages 138-146.\u003cbr\u003e\nMariana Rey, Maria Sol Kruse, Lautaro D. Alvarex, Alberto A. Ghini, Adriana S. Veleiro, Gerardo Burton, Hector Coirini. Neuroprotective action of synthetic steroids with oxygen bridge. Activity on GABAA receptor. Experimental Biology. November 2013. Volume 249, pages 49-58.\u003cbr\u003e\nMammele Stefana, Frauenknecht Katrina, Sevimli Sevgi, Diederich Kai, Bauer Henrike, Grimm Christina, Minnerup Jens, Schäbitz Wolf-Rüdiger, Sommer Clemens J. Restorative Neurology and Neuroscience. 2106. Volume 34, no. 4, pages 665-675 Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-114.1\u003cbr\u003e\nSpecific Activity-5 - 40 Ci\/mmol (185 - 1480 GBq\/mmol)\u003cbr\u003e\nCAS Number-2763-96-4\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol : water (1:1)\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Nominally Labeled\u003cbr\u003e\nMolecular Formula-C4H6N2O2\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Benzodiazepine GABAA\u003cbr\u003e\nShipping Information-Shipped in Dry Ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775354491049,"sku":"NET574250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net574250uc","provider":"Iright","version":"1.0","type":"link"}