{"product_id":"revvity-net594250uc","title":"Revvity, NET594250UC, Pyrilamine (Mepyramine), [pyridinyl 5- H]-, 250µCi (9.25MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\nPyrilamine is an antihistamine that acts as an antagonist at the histamine H1 receptor. These receptors belong to a family of GPCRs that are potential drug targets for allergy.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET594:\u003c\/p\u003e\n\n\u003cp\u003eJin, C. Y., Kalimo, H. and Panula, P. (2002), The histaminergic system in human thalamus: correlation of innervation to receptor expression. European Journal of Neuroscience, 15: 1125–1138.\u003cbr\u003e\nOhta, K., Hayashi, H., Mizuguchi, H., Kagamiyama, H., Fujimoto, K., Fukui, H. (1994), Site-Directed Mutagenesis of the Histamine H1 Receptor: Roles of Aspartic Acid107, Asparagine198 and Threonine194. Biochemical and Biophysical Research Communications, 203 (2): 1096-1101. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-287\u003cbr\u003e\nSpecific Activity-20 - 30 Ci\/mmol (740 - 1110 GBq\/mmol)\u003cbr\u003e\nCAS Number-91-84-9\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-0.25% ascorbic acid in ethanol\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C17H23N3O\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Histamine\u003cbr\u003e\nShipping Information-Shipped Ambient\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-Inflammation\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775381688489,"sku":"NET594250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net594250uc","provider":"Iright","version":"1.0","type":"link"}