{"product_id":"revvity-net678005mc","title":"Revvity, NET678005MC, Norepinephrine, Levo-[ring-2,5,6- H]-, 5mCi (185MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\n5 mCi quantities of Norepinephrine, Levo-[ring-2,5,6-3H]-. Norepinephrine (NA) is a neurotransmitter and hormone that increases heart rate and blood pressure, and is involved in the fight-or-flight response. It is widely used to treat low blood pressure.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET678:\u003c\/p\u003e\n\n\u003cp\u003eAuch-Schwelk, W., Starke, K. and Steppeler, A. (1983), Experimental conditions required for the enhancement by α-adrenoceptor antagonists of noradrenaline release in the rabbit ear artery. British Journal of Pharmacology, 78: 543–551.\u003cbr\u003e\nBryan-Lluka, L., Siebert, G. \u0026amp; Pond, S. (1999) Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells. Naunyn-Schmiedeberg's Arch Pharmacol, 360: 109. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-169.2\u003cbr\u003e\nSpecific Activity-\u0026gt;20 Ci\/mmol (\u0026gt;740 GBq\/mmol)\u003cbr\u003e\nCAS Number-51-41-2\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-0.2N acetic acid : ethanol solution, (9:1)\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C8H11NO3\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Adrenoceptors\u003cbr\u003e\nShipping Information-Shipped in Dry Ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-Cardiovascular CNS \u0026amp; Neurologic Metabolic Disorders\u003cbr\u003e\nUnit Size-5 mCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775360487593,"sku":"NET678005MC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net678005mc","provider":"Iright","version":"1.0","type":"link"}