{"product_id":"revvity-net719250uc","title":"Revvity, NET719250UC, Naloxone, [N-allyl-2,3,- H]-","description":"\u003cp\u003eOverview\u003cbr\u003e\nNaloxone functions as a non-selective, competitive antagonist at opioid receptors. It commonly used to reverse the effects of opioid overdose and to prevent opioid abuse.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET719:\u003c\/p\u003e\n\n \u003cp\u003eAndrei Sonnabend, Viola Spahn, Marlitt Stech, Anne Zemella, Christoph Stein, Stefan Kubick. Production of G protein-coupled receptors in an insect-based cell-free system. Biotechnology and Bioengineering. October 2017. Volume 114, Issue 10, pages 2328-2338.\u003cbr\u003e\nPeter Heusler, Stephanie Tardif, Didier Cussac. Agonist stimulation of human µ opioid receptors in a [35S]GTPγS incorporation assay: observation of “bell-shaped” concentration-response relationships under conditions of strong receptor G protein coupling. Journal of Receptors and Signal Transduction. 2016. Volume 36, Issue 2, pages 158-166.\u003cbr\u003e\nMichael B Gatch, Alexey Kozlenkov, Ren-Qi Huang, Wenjuan Yang, Jacques D Nguyen, Javier Gonzalex-Maeso, Kenner C Rice, Charles P France, Glenn H Dillon, Michael J Forster, John A Schetz. The HIV Antiretroviral Drug Egavierenz has LSD-like Properties. Neuropsychopharmacology. May 2013. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-327\u003cbr\u003e\nSpecific Activity-≥40 Ci\/mmol (≥1480 GBq\/mmol)\u003cbr\u003e\nCAS Number-465-65-6\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Nominally Labeled\u003cbr\u003e\nMolecular Formula-C19H21NO\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Opioid\u003cbr\u003e\nShipping Information-Shipped in dry ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic Inflammation Pain\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775354589353,"sku":"NET719250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net719250uc","provider":"Iright","version":"1.0","type":"link"}