{"product_id":"revvity-net823250uc","title":"Revvity, NET823250UC, Prazosin, [7-Methoxy- H]-, 250µCi (9.25MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\n250 µCi quantities of Prazosin, [7-Methoxy-3H]-, are available for your research. Prazosin is an α1-blocker, and is used to treat high blood pressure, anxiety, and post-traumatic stress disorder. It binds the α1-adrenergic receptor, a GPCR that plays a role in vasconstriction and appetite suppression.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET823:\u003c\/p\u003e\n\n\u003cp\u003eOshita, M., Kigoshi, S. and Muramatsu, I. (1991), Three distinct binding sites for [3H]-prazosin in the rat cerebral cortex. British Journal of Pharmacology, 104: 961–965.\u003cbr\u003e\nHanft, G., Gross, G., Beckeringh, J. J. and Korstanje, C. (1989), α1-Adrenoceptors: the ability of various agonists and antagonists to discriminate between two distinct [3H]prazosin binding sites. Journal of Pharmacy and Pharmacology, 41: 714–716. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-382.4\u003cbr\u003e\nSpecific Activity-70 - 87 Ci\/mmol (2590 - 3219 GBq\/mmol)\u003cbr\u003e\nCAS Number-19216-56-9\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol : 0.01N hydrochloric acid (1:1)\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C19H21N5O4\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Adrenoceptors\u003cbr\u003e\nShipping Information-Shipped in dry ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-Cardiovascular CNS \u0026amp; Neurologic Metabolic Disorders\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775379525801,"sku":"NET823250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net823250uc","provider":"Iright","version":"1.0","type":"link"}