{"product_id":"revvity-net847001mc","title":"Revvity, NET847001MC, Diltiazem, cis-(+)-[N-Methyl- H]-, 1mCi (37MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\n1mCi quantities of Diltiazem, cis-(+)-[N-Methyl-3H]-, are available for your research. Diltiazem is a nondihydropyridine (non-DHP) calcium channel blocker used to treat hypertension and arrythmia.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET847:\u003c\/p\u003e\n\n\u003cp\u003eRupniak, N.M.J., Boyce, S., Williams, A.R., Cook, G., Longmore, J., Seabrook, G.R., Caeser, M., Iversen, S.D. and Hill, R.G. (1993), Antinociceptive activity of NK1 receptor antagonists: non-specific effects of racemic RP67580. British Journal of Pharmacology, 110: 1607–1613.\u003cbr\u003e\nHans Schoemaker, Polyamines allosterically modulate [3H]nitrendipine binding to the voltage-sensitive calcium channel in rat brain, In European Journal of Pharmacology: Molecular Pharmacology, Volume 225, Issue 2, 1992, Pages 167-169. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-414.5\u003cbr\u003e\nSpecific Activity-60 - 87 Ci\/mmol (2220 - 3219 GBq\/mmol)\u003cbr\u003e\nCAS Number-42399-41-7\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C22H26N2O4S\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Calcium\u003cbr\u003e\nShipping Information-Shipped in dry ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--80°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic Pain\u003cbr\u003e\nUnit Size-1 mCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775205757097,"sku":"NET847001MC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net847001mc","provider":"Iright","version":"1.0","type":"link"}