{"product_id":"revvity-net886250uc","title":"Revvity, NET886250UC, TCP, [Piperdyl-3,4-3H(N)]-, 250 µCi","description":"\u003cp\u003eOverview\u003cbr\u003e\nTCP acts as an antagonist at N-methyl-D-aspartate receptor (NMDA receptors), and is a dissociative anesthetic drug with hallucinogenic effects.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET886:\u003c\/p\u003e\n\n\u003cp\u003eZ. Kawakami, H. Kanno, T. Ueki, K. Terawaki, M. Tabuchi, Y. Ikarashi, Y. Kase, Neuroprotective effects of yokukansan, a traditional japanese medicine, on glutamate-mediated excitotoxicity in cultured cells, Neuroscience, Volume 159, Issue 4, 2009, Pages 1397-1407.\u003cbr\u003e\nMatthew A. Sills, Graham Fagg, Mario Pozza, Christof Angst, Derek E. Brundish, Stephen D. Hurt, E. Jay Wilusz, Michael Williams, [3H]CGP 39653: a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain, European Journal of Pharmacology, Volume 192, Issue 1, 1991, Pages 19-24. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-249.24\u003cbr\u003e\nSpecific Activity-40 - 60 Ci\/mmol (1480 - 2220 GBq\/mmol)\u003cbr\u003e\nCAS Number-96-18-4\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Nominally Labeled\u003cbr\u003e\nMolecular Formula-C15H23NS\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Glutamate\u003cbr\u003e\nShipping Information-Shipped in dry ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775396204713,"sku":"NET886250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net886250uc","provider":"Iright","version":"1.0","type":"link"}