{"product_id":"revvity-net918250uc","title":"Revvity, NET918250UC, GBR 12935, [Propylene-2,3- H]-, 250µCi (9.25MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\nGBR 12935 acts as an antagonist of the dopamine transporter, and is used in animal research into Parkinson's disease and dopamine pathways in the brain.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET918:\u003c\/p\u003e\n\n\u003cp\u003ePaul Berger, John D. Elsworth, Jorge Arroyo, Robert H. Roth, Interaction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbens, In European Journal of Pharmacology, Volume 177, Issues 1–2, 1990, Pages 91-94.\u003cbr\u003e\nPeter H. Andersen, J.Aas Jansen, Erik B. Nielsen, [3H]GBR 12935 binding in vivo in mouse brain: labelling of a piperazine acceptor site, In European Journal of Pharmacology, Volume 144, Issue 1, 1987, Pages 1-6. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-414.6\u003cbr\u003e\nSpecific Activity-≥20 Ci\/mmol (≥740 GBq\/mmol)\u003cbr\u003e\nCAS Number-67469-81-2\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C28H34N2O\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Dopamine Transporter\u003cbr\u003e\nShipping Information-Shipped in dry ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775213424809,"sku":"NET918250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net918250uc","provider":"Iright","version":"1.0","type":"link"}