{"product_id":"revvity-net950250uc","title":"Revvity, NET950250UC, Ryanodine, [9,21- H(N)]-, 250µCi (9.25MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\nRyanodine is a plant alkaloid and natural ligand for the ryanodinen receptor (RyR), a class of calcium channels (Ca2+ channels).\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET950:\u003c\/p\u003e\n\n\u003cp\u003eAraki, T., Kato, H., Shuto, K., Oshima, Y. and Itoyama, Y. (1998), Postischemic changes of [3H]nimodipine and [3H]ryanodine binding in the gerbil striatum and hippocampus. European Journal of Neurology, 5: 195–201. Concentration-0.1 mCi\/ml\u003cbr\u003e\nMolecular Weight-493.5\u003cbr\u003e\nSpecific Activity-50 - 100 Ci\/mmol (1850 - 3700 GBq\/mmol)\u003cbr\u003e\nCAS Number-15662-33-6\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Nominally Labeled\u003cbr\u003e\nMolecular Formula-C25H35NO9\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Calcium\u003cbr\u003e\nShipping Information-Shipped in dry ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic Musculoskeletal\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775385129129,"sku":"NET950250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net950250uc","provider":"Iright","version":"1.0","type":"link"}