{"product_id":"revvity-net952250uc","title":"Revvity, NET952250UC, U-69,593, [Phenyl-3,4- H]-, 250µCi (9.25MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\nU-69,593 acts as an agonist at kappa 1 opioid receptors (KORs). These receptors are a class of GPCRs involved in pain, consciousness, stress, and mood.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET952:\u003c\/p\u003e\n\n\u003cp\u003eMeng F, Xie GX, Thompson RC, Mansour A, Goldstein A, Watson SJ, and Akil H (1993) Cloning and pharmacological characterization of a rat kappa opioid receptor. Proc Natl Acad Sci USA 90:9954–9958. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-356.5\u003cbr\u003e\nSpecific Activity-30 - 60 Ci\/mmol (1110 - 2220 GBq\/mmol)\u003cbr\u003e\nCAS Number-96744-75-1\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C22H32N2O2\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Opioid\u003cbr\u003e\nShipping Information-Shipped in dry ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic Inflammation Pain\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775402660009,"sku":"NET952250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net952250uc","provider":"Iright","version":"1.0","type":"link"}