{"product_id":"revvity-net964250uc","title":"Revvity, NET964250UC, AH5183, L-[Piperidinyl-3,4- H]-(Vesamicol), 250 µCi","description":"\u003cp\u003eOverview\u003cbr\u003e\nAH5183 (vesamicol, (2-hydroxyethyl)-1-piperazine-ethanesulfonic acid, (4-phenylpiperidino) cyclohexanol) is a cholinergic vesicular uptake blocker. Vesicular acetylcholine transporters (VAChT) are neurotransmitter transporters involved in acetylcholine secretion. Vesamicol inhibits the transport of acetylcholine into synaptic vesicles in nerve terminals, and play a role in drug response and vulnerability to drug addiction.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET964:\u003c\/p\u003e\n\n\u003cp\u003eOjeda A.M., Bravo D.T., Hart T.L., Parsons S.M. (2003) Equilibrium Binding and Transport Studies. In: Yan Q. (eds) Membrane Transporters. Methods in Molecular Biology, vol 227. Humana Press. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-259.4\u003cbr\u003e\nSpecific Activity-25 - 60 Ci\/mmol (925 - 2220 GBq\/mmol)\u003cbr\u003e\nCAS Number-22232-64-0\u003c\/p\u003e\n\n\u003cp\u003eApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C17H25NO\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Vesicular Amine Transporters (VATs)\u003cbr\u003e\nShipping Information-Shipped on Dry Ice\u003cbr\u003e\nShipping Conditions-Shipped in Blue Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46774515204265,"sku":"NET964250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net964250uc","provider":"Iright","version":"1.0","type":"link"}