{"product_id":"revvity-net975250uc","title":"Revvity, NET975250UC, Raclopride, [Methoxy- H]-, 250µCi (9.25MBq)","description":"\u003cp\u003eOverview\u003cbr\u003e\nRaclopride is a synthetic compound that acts as a selective antagonist at dopamine D2 receptors. These receptors are potential drug targets for schizophrenia, Parkinson's disease, and other neurological conditions.\u003cbr\u003e\nWe offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.\u003cbr\u003e\nRadiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NET975:\u003c\/p\u003e\n\n\u003cp\u003eSørensen, G., Sager, T.N., Petersen, J.H. et al. Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice, Psychopharmacology (2008) 199: 37-46.\u003cbr\u003e\nChen, J., Su, H., Huang, L., Hsieh, M. Reductions in binding and functions of D2 dopamine receptors in the rat ventral striatum during amphetamine sensitization, Life Sciences (1998) 64 (5): 343-354. Concentration-1 mCi\/ml\u003cbr\u003e\nMolecular Weight-346.2\u003cbr\u003e\nSpecific Activity-60 - 87 Ci\/mmol (2220 - 3219 GBq\/mmol)\u003cbr\u003e\nCAS Number-84225-95-6\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Ethanol\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C15H20Cl2N2O3\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-3 H\u003cbr\u003e\nReceptor-Dopamine\u003cbr\u003e\nShipping Information-Shipped in dry ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic\u003cbr\u003e\nUnit Size-250 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775382245545,"sku":"NET975250UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-net975250uc","provider":"Iright","version":"1.0","type":"link"}