{"product_id":"revvity-nex110100uc","title":"Revvity, NEX110100UC, Triiodothyronine, ([ I]-T3), L-3,5,3'-[ I]-, 100 µCi (3.7 MBq), Specific Activity: 135-165 µCi (5.00-6.11 MBq)\/µg","description":"\u003cp\u003eOverview\u003cbr\u003e\n100 µCi quantities of Triiodothyronine, ([125I]-T3), L-3,5,3'-[125I]-, are available for your research.\u003cbr\u003e\nWe offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.\u003cbr\u003e\nRadiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NEX110:\u003c\/p\u003e\n\n\u003cp\u003eMcIver, C.R., Shaw, IC., Gin, S., Ellis, M.J. (2013), Can thyroid hormone mimics affect thyroid hormone measurement by immunoassay?, Clinical Biochemistry, Volume 46, Issues 13–14, Pages 1302-1304.\u003cbr\u003e\nMantzos, J.D., Yialouris, P.P. (1982), A simple and reproducible method for the estimation of triiodothyronine uptake (thyroxine binding index) using a new adsorbent, Clinical Biochemistry, Volume 15, Issue 2, Pages 76-79.\u003c\/p\u003e\n\n\u003cp\u003eReferences for NEX110H:\u003c\/p\u003e\n\n\u003cp\u003eMcConway, M.G., Chapman, R.S. (1986) Application of solid-phase antibodies to radioimmunoassay Evaluation of two polymeric microparticles, Dynospheres and nylon, activated by carbonyldiimidazole or tresyl chloride, Journal of Immunological Methods, Volume 95, Issue 2, Pages 259-266.\u003cbr\u003e\nSelliti, D.F., Latham, K.R. (1983) Multiple affinity classes of saturable triiodothyronine binding in mouse liver nuclear extract demonstrated using high-performance size exclusion chromatography, Journal of Chromatography A, Volume 268, Pages 300-305.\u003c\/p\u003e\n\n \u003cp\u003eReferences for NEX110X:\u003c\/p\u003e\n\n\u003cp\u003eGlynn, N., Kenny, H., Quisenberry, L., Halsall, D. J., Cook, P., Kyaw Tun, T., McDermott, J. H., Smith, D., Thompson, C. J., O'Gorman, D. J., Boelen, A., Lado-Abeal, J. and Agha, A. (2017), The effect of growth hormone replacement on the thyroid axis in patients with hypopituitarism: in vivo and ex vivo studies. Clin Endocrinol, 86: 747–754. Molecular Weight-649\u003cbr\u003e\nSpecific Activity-135 - 165 µCi (5.00 - 6.11 MBq)\/µg\u003cbr\u003e\nCAS Number-6893-02-3\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Propanol : water (1:1)\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nFresh Lot Days-Third Monday of each month\u003cbr\u003e\nLabel Position-Specifically Labeled\u003cbr\u003e\nMolecular Formula-C15H12I3NO4\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-125 I\u003cbr\u003e\nShipping Information-Shipped Ambient\u003cbr\u003e\nShipping Conditions-Shipped Ambient\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions-4°C\u003cbr\u003e\nTherapeutic Area-Metabolic Disorders\u003cbr\u003e\nUnit Size-100 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775401939113,"sku":"NEX110100UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-nex110100uc","provider":"Iright","version":"1.0","type":"link"}