{"product_id":"revvity-nex306050uc","title":"Revvity, NEX306050UC, Sauvagine, [ I]-Tyr ], 50µCi","description":"\u003cp\u003eOverview\u003cbr\u003e\n50 µCi Quantities of Sauvagine, [125I]-Tyr0] are available for your research.\u003cbr\u003e\nWe offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.\u003cbr\u003e\nRadiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NEX306:\u003c\/p\u003e\n\n\u003cp\u003eOakley, R.H., Olivares-Reyes, J.A., Hudson, C.C., Flores-Vega, F., Dautzenberg, F.M., Hauger, R.L. (2007), Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses. Am J Phsiol Regul Integr Comp Physiol., 293 (1): R209-222.\u003cbr\u003e\nMillion, M., Grigoriadis, D.E., Sullivan, S., Crowe, P.D., McRoberts, J.A., Zhou, H., Saunders, P.R., Maillot, C., Mayer, E.A., Taché, Y. (2003), A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Res, 985 (1): 32-42. Molecular Weight-4778\u003cbr\u003e\nSpecific Activity-2200 Ci\/mmol  (81.4 TBq\/mmol)\u003cbr\u003e\nCAS Number-74434-59-6\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Acetonitrile : water (35:65), 0.05M mercaptoethanol, 0.2% TFA, and 0.2% BSA\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nFresh Lot Days-Fourth Monday of each month\u003cbr\u003e\nLabel Position-Nominally Labeled\u003cbr\u003e\nMolecular Formula-C202H346N56O63S\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-125 I\u003cbr\u003e\nReceptor-Corticotropin-releasing factor\u003cbr\u003e\nShipping Information-Shipped Ambient\u003cbr\u003e\nShipping Conditions-Shipped Ambient\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions-4°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic Inflammation\u003cbr\u003e\nUnit Size-50 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775385424041,"sku":"NEX306050UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-nex306050uc","provider":"Iright","version":"1.0","type":"link"}