{"product_id":"revvity-nex388025uc","title":"Revvity, NEX388025UC, Ghrelin (human), [His[ I]], 25µCi","description":"\u003cp\u003eOverview\u003cbr\u003e\n25 µCi Quantities of Ghrelin (human), [His[125I]] are available for your research.\u003cbr\u003e\nWe offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.\u003cbr\u003e\nRadiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NEX388:\u003c\/p\u003e\n\n\u003cp\u003eGauna, C., van de Zande, B., van Kerkwijk, A., Themmen, A.P., van der Lely, A.J., Delhanty, P.J. (2007), Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R). Mol Cell Endocrinol, 274 (1-2): 30-34.\u003cbr\u003e\nLeung, P.K., Chow, K.B., Lau, P.N., Chu, K.M., Chan, C.B., Cheng, C.H., Wise, H. (2007), The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor. Cell Signal, 19 (5): 1011-1022. Molecular Weight-3495\u003cbr\u003e\nSpecific Activity-2200 Ci\/mmol  (81.4 TBq\/mmol)\u003cbr\u003e\nCAS Number-258279-04-8\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-0.1% trifluroacetic acid and 0.4% BSA : 46% 1-propanol and 54% acetonitrile  (1:1)\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nFresh Lot Days-Fourth Monday of each month\u003cbr\u003e\nHost Species-Human\u003cbr\u003e\nLabel Position-Nominally Labeled\u003cbr\u003e\nMolecular Formula-C149H249N47O42\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-125 I\u003cbr\u003e\nReceptor-Ghrelin\u003cbr\u003e\nShipping Information-Shipped on Dry Ice\u003cbr\u003e\nShipping Conditions-Shipped in Dry Ice\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions--20°C\u003cbr\u003e\nTherapeutic Area-CNS \u0026amp; Neurologic Obesity\u003cbr\u003e\nUnit Size-25 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775213752489,"sku":"NEX388025UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-nex388025uc","provider":"Iright","version":"1.0","type":"link"}