{"product_id":"revvity-nex423010uc","title":"Revvity, NEX423010UC, Calcitonin [Tyr22] (salmon), [ I] 10 µCi","description":"\u003cp\u003eOverview\u003cbr\u003e\n10 µCi Quantities of Calcitonin [Tyr22] (salmon), [125I] are available for your research.\u003cbr\u003e\nWe offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.\u003cbr\u003e\nRadiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, Revvity has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.\u003cbr\u003e\nReferences for NEX420:\u003c\/p\u003e\n\n\u003cp\u003eCascieri, M. A. et al. Mutants of human insulin-like growth factor I with reduced affinity for the type 1 insulin-like growth factor receptor. Biochemistry 27, 3229–3233 (1988).\u003cbr\u003e\nChou, Y.-H., Kuo, W.-L., Rosner, M. R., Tang, W.-J. \u0026amp; Goldman, R. D. Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme. The FASEB Journal 23, 3734–3742 (2009). Molecular Weight-3555.9\u003cbr\u003e\nSpecific Activity-2200 Ci\/mmol  (81.4 TBq\/mmol)\u003cbr\u003e\nCAS Number-47931-85-1\u003cbr\u003e\nApplication-Drug Discovery \u0026amp; Development\u003cbr\u003e\nBrand-NEN Radiochemicals\u003cbr\u003e\nBuffer\/Solvent-Lyophilized\u003cbr\u003e\nDetection Modality-Radiometric\u003cbr\u003e\nFresh Lot Days-Fresh upon request\u003cbr\u003e\nLabel Position-Nominally Labeled\u003cbr\u003e\nPackaging-NENSure vial\u003cbr\u003e\nRadioisotope-125 I\u003cbr\u003e\nReceptor-Calcitonin\u003cbr\u003e\nShipping Information-Ambient\u003cbr\u003e\nShipping Conditions-Shipped Ambient\u003cbr\u003e\nSpecial Ordering Information-This is a radioactive product - shipping address must have a license to receive radioactive materials.\u003cbr\u003e\nStorage Conditions-4°C\u003cbr\u003e\nTherapeutic Area-Angiogenesis Cardiovascular Inflammation\u003cbr\u003e\nUnit Size-10 µCi\u003c\/p\u003e","brand":"Revvity","offers":[{"title":"Default Title","offer_id":46775193764009,"sku":"NEX423010UC","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/revvity-nex423010uc","provider":"Iright","version":"1.0","type":"link"}