Agilent, PL1580-5301, 1 AdvanceBio SEC 300Å, 4.6 x 300 mm, 2.7 µm, HPLC column

1 AdvanceBio SEC 300Å, 4.6 x 300 mm, 2.7 µm, HPLC column. A size exclusion column for efficient aggregate analysis of proteins, including monoclonal antibodies. The resolving range is 5-1,250 kDa.

Specifications:
Brand: AdvanceBio SEC
Hardware: SS
Inner Diameter (ID): 4.6 mm
LC Platform: Stainless Steel
Length: 300 mm
Maximum Temperature: 80 °C
Molecular Weight Lower Limit: 5000 Da
Molecular Weight Upper Limit: 1250000 Da
Part Number Application Domain: Biopharma
Part Number Application: Aggregate & Fragment AnalysisMonoclonal Antibodies (mABs)Proteins
Particle Size: 2.7 µm
Particle Type: Fully Porous
Phase: SEC
Pore Size: 300 Å
Pressure Rating: 400 bar
Separation Mode: Size Exclusion (SEC)
Shipping Solvent: 0.02% Sodium Azide
Technique: LC
UNSPSC Code: 41115711
pH Range: 2-8.5

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Designed for high-resolution size exclusion chromatography, this HPLC column features a 300 angstrom pore size and 2.7 micron particle size in a 4.6 x 300 mm format. It enables precise molecular weight separation and analysis of proteins, antibodies, and other biomolecules, making it ideal for biopharmaceutical characterization and quality control. The advanced particle technology ensures robust performance, excellent reproducibility, and minimized nonspecific interaction, supporting reliable results over repeated runs. Common research applications include aggregation analysis, detection of protein fragments, and the assessment of sample purity in pharmaceutical development, academic research, and quality assurance environments.

This column is fully compatible with standard HPLC and UHPLC systems, including Agilent’s 1100, 1200, and 1260 Infinity Series, as well as comparable industry instruments. It works seamlessly with aqueous SEC applications and can be integrated into workflows with Agilent AdvanceBio SEC standards, mobile phases, and other supporting accessories. The robust construction allows for consistent performance across a range of flow rates and sample types, offering flexibility for both routine analysis and specialized method development. Its reliable performance and ease of integration make it an essential tool for biotherapeutic and protein analysis laboratories.