Cytiva, 17531704, Capto™ MMC multimodal chromatography resin

Capto MMC, 5 L Capto MMC is a multimodal weak cation exchanger that is salt-tolerant. It has a different selectivity, compared with traditional ion exchangers. • Multimodal cation exchanger with a different selectivity than traditional ion exchangers. • High dynamic binding capacity at high conductivity increases productivity. • High-volume throughput cuts process times. • Smaller unit operations give cost-effective processing and reduce investments. • Resin fulfills industrial demands for security of supply, robust performance, and regulatory support. An alternative solution to traditional ion exchangers Capto MMC combines agarose base matrix developments with innovative ligand chemistry. It is composed of a rigid, high-flow agarose matrix and a novel multimodal ligand. The multimodal functionality gives Capto MMC a different selectivity, compared with traditional ion exchangers. This resin can be used to bind proteins at the conductivity of the feed material. It can also be used to solve specific purification challenges at both high and low ionic strengths. Hydrogen bonding and hydrophobic interactions The ligand contains a carboxylic group. Thus, its features partly resemble a weak cation exchanger. Hydrogen bonding and hydrophobic interactions are also involved. Prepacked columns and other formats Capto MMC resin is available in the following formats: Process development scale: prepacked PreDictor Capto MMC filter plates , 96-well plates for high-throughput screening or process development. PreDictor Capto MMC RoboColumn™ units , miniaturized columns for high-throughput process development. HiScreen Capto MMC columns , optimized for method and process development. f(x) column , prepacked and precharacterized chromatography column for fast and accurate mechanistic modeling. Lab scale: prepacked for manual purification HiTrap Capto MMC columns , for easy use with a syringe, peristaltic pump, or chromatography system. Lab scale: prepacked for automated purification and analysis HiTrap Capto MMC columns , for easy use with a syringe, peristaltic pump, or chromatography system. Process characterization: resin kits Process Characterization Kit Capto MMC , designed for studying the potential impact that resin ligand density might have on the process outcome. Process-scale purification: prepacked ReadyToProcess Capto MMC columns , 1 L and larger columns for clinical manufacturing that minimize the need for cleaning and cleaning validation.