Corning Advanced Cells Collection: Superior Surfaces for Stem Cell & 3D Culture

Corning Advanced Cells presents a high-performance range of cell culture surfaces tailored for advanced research in cell therapy, regenerative medicine, and modern cell biology. Incorporating ECM mimetic, CellBIND, Ultra-Low Attachment, PureCoat, and rLaminin technologies, these products are designed to improve cell attachment, viability, and experimental consistency across diverse cell types, including stem cells, primary cells, and immune cells.

Unlike standard cell culture plastics, Corning Advanced Cells surfaces provide defined, animal component-free environments and cGMP-ready vessels to ensure reliable results from early discovery to clinical manufacturing. This advanced collection supports 2D and 3D culture formats, enabling innovation in drug development, disease modeling, and cell-based therapies.

ECM Mimetic & PureCoat Surfaces

Corning’s ECM mimetic and PureCoat surfaces are engineered to closely replicate the natural extracellular matrix, providing an optimal environment for sensitive and demanding cell types. These advanced coatings incorporate key biomolecules such as fibronectin, collagen, and synthetic peptides like Synthemax, which significantly improve cell attachment, proliferation, and functionality. By offering a defined, animal component-free surface, PureCoat products deliver enhanced compatibility and reproducibility for primary cells, stem cells, and other challenging cultures. These surfaces are ideal for researchers seeking reliable and physiologically relevant conditions for advanced cell culture applications.

CellBIND Surface for Enhanced Cell Attachment and Consistency

Corning CellBIND surfaces utilize a unique plasma treatment process to modify the culture surface at the molecular level, resulting in improved hydrophilicity and uniform surface charge. This advanced technology enables superior cell attachment and growth, even under low-serum or serum-free conditions, making it ideal for sensitive cell types and demanding protocols.

Key Advantages of Corning CellBIND Surfaces:

• Enhanced cell adhesion: Supports robust attachment of a wide range of cells, including difficult-to-culture and primary cells.
• Improved consistency: Provides batch-to-batch uniformity for more reproducible results in cell-based assays.
• Optimized for low-serum media: Maintains high performance with reduced or no serum, helping to lower experimental variability and costs.
• Animal component-free: Offers a defined, non-animal-derived surface, minimizing potential contamination risks.

Ultra‑Low Attachment Surfaces for 3D Cell Culture and Spheroid Formation

Corning Ultra‑Low Attachment (ULA) surfaces are specially designed to prevent cell adhesion, enabling efficient formation of spheroids and aggregate cultures for advanced 3D cell models. These surfaces are ideal for stem cell spheroids, cancer research, suspension cultures, and high-throughput drug screening, providing a consistent and defined environment for complex biological assays.

rLaminin & Synthemax Surfaces for Stem Cell Expansion and Maintenance

Corning rLaminin-521 and Synthemax surfaces offer a defined, xeno-free environment specifically designed to support the robust expansion and self-renewal of human pluripotent and multipotent stem cells. These surfaces promote stable cell attachment, efficient single-cell passaging, and the maintenance of pluripotency over extended culture periods, making them ideal for both advanced research and clinical manufacturing.

Key Benefits:

• Enhanced self-renewal: Maintain stem cell pluripotency without spontaneous differentiation.
• Single-cell passaging: Enable consistent single-cell seeding and expansion, supporting clonal selection and gene editing workflows.
• Xeno-free and animal component-free: Provide a fully defined surface, minimizing variability and supporting regulatory compliance.
• Scalable for clinical applications: Support large-scale stem cell production suitable for translational research and cell therapy manufacturing.

cGMP-Compliant Vessels and Scale-Up Platforms for Industrial Cell Culture

Corning provides a comprehensive range of cGMP-compliant vessels and scale-up platforms to support industrial-scale cell culture and bioprocessing. Engineered for consistency, reliability, and regulatory compliance, solutions such as the CellSTACK multi-layer vessels and HYPERFlask systems enable efficient expansion from research through clinical and commercial production. These advanced platforms are designed for high-throughput workflows, optimized surface area, and robust performance in large-volume applications, meeting the demands of cell therapy and biomanufacturing.

How to Choose the Right Cell Culture Surface for Your Application

Selecting the optimal cell culture surface is essential for achieving consistent results in advanced research and biomanufacturing. Corning Advanced Cells offers a diverse range of surfaces tailored to different cell types, culture formats, and process stages. Understanding your experimental needs will help you choose the most suitable platform for your workflow.

For Adherent Cell Culture (2D):
Researchers working with adherent cell lines or primary cells should consider surfaces such as CellBIND or ECM mimetic coatings. CellBIND surfaces are ideal for robust cell attachment and reproducibility, especially under low-serum or serum-free conditions. ECM mimetic and PureCoat surfaces closely simulate natural extracellular matrices, making them well-suited for sensitive or stem cell populations.

For Suspension and 3D Cultures:
Ultra-Low Attachment surfaces are designed to prevent cell adhesion, promoting the formation of spheroids, aggregates, or organoids. These surfaces are optimal for 3D cell models, cancer research, and suspension cultures of stem or immune cells, as well as for high-throughput drug screening applications.

For Stem Cell Expansion:
For pluripotent or multipotent stem cell research, defined and xeno-free surfaces like rLaminin-521 and Synthemax ensure stable expansion, support single-cell passaging, and maintain pluripotency. These platforms are ideal for gene editing, clonal selection, and scale-up to clinical manufacturing.

For Process Scale-Up and cGMP Manufacturing:
When transitioning from discovery to large-scale production, cGMP-compliant vessels such as CellSTACK and HYPERFlask provide the surface area, regulatory documentation, and workflow efficiency required for cell therapy, vaccine production, or bioprocessing at industrial scale.

Choosing the right surface depends on your cell type, intended culture format, and stage in the research-to-manufacturing pipeline. Corning’s advanced surface technologies are engineered to deliver optimal performance at every step.

Key Applications: 3D Cell Culture, Cell Therapy, and Drug Screening

Corning Advanced Cells surfaces enable a wide range of advanced applications across cell research and manufacturing. These innovative platforms help researchers achieve reliable results in both discovery and clinical settings.

3D Cell Culture & Disease Modeling
Ultra-Low Attachment and ECM mimetic surfaces support the formation of spheroids and organoids, creating more physiologically relevant models for cancer research and disease studies.

Cell Therapy Manufacturing
cGMP-compliant vessels such as CellSTACK and HYPERFlask facilitate large-scale expansion of therapeutic cells, ensuring safety, consistency, and compliance for clinical and commercial production.

High-Throughput Drug Screening
Specialized surfaces like Ultra-Low Attachment and PureCoat are ideal for automated drug screening, supporting robust 3D models and reliable efficacy testing.

Stem Cell Research & Gene Editing
rLaminin-521 and Synthemax provide a defined environment for the expansion and maintenance of pluripotent stem cells, making them ideal for gene editing and regenerative medicine.