Thermo Fisher Stoppers & Closures for Vials, GL45 Bottles, and Chromatography

Stoppers and closures keep your samples sealed, clean, and consistent—from chromatography autosamplers to GL-thread bottles and serum vials. On this page, you’ll compare Thermo Fisher options by size, liner, sterility, and compatibility—and request sourcing through Iright, an authorized distributor for a broad range of Thermo Fisher products.

What Are Thermo Fisher Stoppers & Closures? (And Why Buy from Iright)

Choosing the right closure is about fit and function: thread or crimp dimensions, liner chemistry, temperature limits, and sterility all influence performance. As your distributor, Iright helps you select exact Thermo Fisher matches, align with instrument requirements, and consolidate purchasing across SureSTART™ vials, Nalgene™ bottles, and serum vials.

Stoppers serve two core jobs: reliable sealing and predictable interaction with your sample. Thermo Fisher designs include PTFE/silicone or PTFE/butyl liners for low bleed, halobutyl rubber for serum finishes, and specialized GL45 assemblies for sterile transfers—each tuned for autosampler needles, freeze-dry workflows, or aseptic handling.

Key Selection Factors: Size, Material, Sterility & Compatibility

Before diving into SKUs, narrow your options using four levers: (1) container and finish (9-mm screw, 11-mm crimp, 13/20-mm serum, GL45 threads), (2) liner or rubber material, (3) sterility and sterilization method, and (4) instrument or process constraints like needle punctures or aseptic transfers.

A correct finish prevents leaks and needle damage; liners such as PTFE/silicone balance chemical resistance with resealability; sterile or autoclavable designs safeguard workflows; and compatibility with LC/GC autosamplers or bottle manifolds keeps throughput smooth. These are the factors you’ll filter for below and cross-check in our spec table with real Thermo Fisher catalog numbers.

• Fit/finish basics: 9-mm screw caps for 12×32 mm vials; 11-mm crimp systems; 13/20 mm serum finishes; GL45 for media/storage bottles.

• Liner and rubber: PTFE/silicone for broad chemical resistance; PTFE/butyl for tight gas sealing; halobutyl stoppers for serum vials.

• Sterility & sterilization: options vary by SKU—some caps/closures are supplied sterile or are autoclavable; check product pages before purchase.

Product Families & Use Cases: Vial Stoppers, Caps & Septa, GL45 Closures

To keep your navigation efficient, we group SKUs by container family. Start with your container, then drill down by finish and liner. Each family aligns to typical applications—chromatography, sample storage, lyophilization, or sterile transfer—so you can move from “what you use” to “what you need” in a few clicks.

SureSTART™ Caps & Septa (9-mm screw / 11-mm crimp) — optimized for LC/GC autosamplers; Level 1–3 tiers balance routine to high-performance methods and reduce needle coring with AVCS™ designs. Ideal for labs standardizing vial components across instruments.

Serum Vial Stoppers (13/20 mm) — halobutyl stoppers for sealing serum vials; choose by finish and pack size for QC retains, lyophilization, or sample archiving.

Nalgene™ GL45 Closures — sterile/aseptic closure assemblies and drip-free caps for GL45 bottles; use for sterile transfers, media filtration, or closed-loop operations.

Popular Specs at a Glance: Caps & Septa Comparison Table

The table below lists representative, verified Thermo Fisher catalog numbers to help you anchor choices. Use it to compare finishes, liner materials, and pack sizes; then follow the product link when you’re ready to view every variant and certificate.

Filters & Navigation: Find the Right Thermo Scientific Closure Faster

Filters turn a long list into a shortlist. Configure them by the attributes buyers actually use—container family first, then finish, liner, sterility, and pack/colour. On mobile, keep filters collapsible; on desktop, pin the most-used facets so users reach a match within two to three clicks.

• Container Type: Vials (2 mL/12×32 mm), Serum Vials (13/20 mm), GL-Thread Bottles (GL45/GL32)
• Finish: 9-mm screw, 11-mm crimp, 13/20-mm serum, GL45
• Liner/Rubber: PTFE/silicone, PTFE/butyl, halobutyl, natural rubber
• Sterility/Sterilization: Sterile, non-sterile; autoclavable, gamma-stable (as applicable per SKU)
• Pack & Colour: 100/pk, 1000/pk, 5000/pk; black/blue/white/red caps
• Use Case: LC/GC autosampler, sample storage, lyophilization, aseptic transfer

Chemical, Thermal & Instrument Compatibility (LC/GC, Autosamplers)

Compatibility reduces troubleshooting later. Provide a quick principles guide here and let users drill down to data sheets for exact limits. For chromatography, highlight low-bleed liners and robust resealability; for GL45 systems, emphasize aseptic flow paths and bottle fit.

Chemistry: PTFE-faced septa offer broad solvent resistance; butyl liners improve gas-tightness; halobutyl stoppers suit serum finishes. Check the product’s chemical compatibility notes before use with aggressive organics.

Temperature & Sterilization: Many PP caps and silicone/PTFE liners are autoclavable; aseptic GL45 closures are designed for sterile workflows—validate time/temperature against the product page.

Instruments: AVCS™ screw caps help prevent over-/under-tightening and septa push-through, protecting autosampler needles and improving seal consistency at scale.

FAQ: Stoppers, GL45 Caps, and Septa—Quick Answers

Use this section to pre-empt common mistakes and reduce back-and-forth. Keep answers short, link to a family page when variability exists, and avoid absolute claims where performance depends on a defined combination of parts and test methods.

Q1. Are 9-mm screw caps interchangeable across all 12×32 mm vials?
They’re designed for 9-mm screw-finish vials. Stay within SureSTART™ families for best autosampler performance and to access matching septa hardness and AVCS™ features. 

Q2. Which septa should I choose for GC versus LC?
Both need low bleed and resealability; silicone/PTFE is common for LC, while GC workflows often select butyl-based stoppers or low-bleed septa. Verify with your solvent system and temperature program.

Q3. Do GL45 closures fit any GL45 bottle?
They’re built for GL45 threads, but specialized assemblies (e.g., Top Works™ aseptic closures) are intended for Nalgene™ compatible systems—check your bottle family and intended use.

Q4. Can I autoclave these components?
Many caps/liners can be autoclaved; others are supplied sterile or designed for aseptic use. Always confirm the specific product’s sterilization instructions and materials list on the product page.

Q5. How do I reduce needle coring and carryover in high-throughput runs?
Use AVCS™ caps with suitable septa hardness, avoid over-tightening, and replace septa at recommended intervals. SureSTART™ Level 2–3 components are designed for robustness.

Talk to Iright

If you already know your container and finish, share that with us and we’ll propose matched SKUs plus alternates for lead-time resilience. If you’re still comparing, send your solvent system, temperature limits, sterility needs, and autosampler model; Iright will respond with a short-list and documentation links for sign-off.