Agilent, 5190-2427, Agilent Bio SCX, NP5, 4.6 x 250 mm, PEEK

Agilent Bio SCX, NP5, 4.6 x 250 mm, PEEK. A strong cation exchange HPLC column with nonporous particles. Particle size is 5 μm. PEEK hardware enables this column to couple with bio-compatible or bio-inert LC systems.

Specifications:
Brand: Agilent Bio SCX
Column Material: PEEK
Hardware: PEEK
Inner Diameter (ID): 4.6 mm
LC Platform: BioInert
Length: 250 mm
Maximum Temperature: 80 °C
Part Number Application Domain: Biopharma
Part Number Application: Charge Variant AnalysisPeptidesProteins
Particle Size: 5 µm
Particle Type: Non-porous
Phase: SCX
Pressure Rating: 413 bar
Separation Mode: Ion Exchange (IEX)
Shipping Solvent: Phosphate Buffer
Technique: LC
UNSPSC Code: 41115711
pH Range: 2-12

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The Agilent Bio SCX NP5 4.6 x 250 mm PEEK column is engineered to deliver reliable and high-resolution separation of proteins, peptides, and biomolecules based on charge differences using strong cation exchange chromatography. Its 4.6 mm inner diameter and 250 mm length provide optimal balance between resolution and loading capacity, making it suitable for both analytical and preparative applications in biopharmaceutical analysis, proteomics, and quality control laboratories.

Constructed with PEEK hardware, the column ensures chemical inertness and compatibility with a wide range of biological samples, minimizing potential adsorption and metal-induced sample degradation. The NP5 stationary phase offers excellent selectivity and durability, supporting reproducible performance across routine and high-throughput workflows.

This column is compatible with Agilent 1100, 1200, and 1290 Infinity series HPLC and UHPLC systems, as well as most standard liquid chromatography platforms, facilitating seamless integration into existing workflows. It is well-suited for the separation of monoclonal antibodies, therapeutic proteins, and charge variants, supporting method development for regulatory submissions and detailed characterization studies. For expanded ion exchange capabilities, it may be paired with other Agilent Bio IEX columns tailored to specific application needs.