Thermo Fisher, 27-1602-12, TheraPure™ 2'-Fluoro-U Phosphoramidite, 28-400 finish bottle

Thermo Fisher, 27-1602-12, TheraPure™ 2'-Fluoro-U Phosphoramidite, 28-400 finish bottle 2'-Fluoro-U CEP is a phosphoramidite containing 5' DMT and the nucleoside uridine (U) with 2'-Fluoro protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, the highly electronegative fluorine (2'-Fluoro) modification adopts a more thermodynamically stable A-form helix on hybridization to its target. Showing improved affinity and some nuclease resistance (compared to 2'-OH), the 2'-F modification has been proven useful in antisense, siRNA, and aptamer applications. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 30-mL amber bottle with a 28-400 finish neck style, which is compatible with most MerMade synthesizers.
Features:
• Full chemical name—5'-O-(4,4'-Dimethoxytrityl)-2'-fluorouridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula—C39H46FN4O8P
• Base—A
• Formula weight—748.
8 g/mol
• CAS number—146954-75-8
• HPLC purity—>98%
•31P NMR purity—≥98%For Use With (Equipment): MerMade Synthesizers
Form: Powder
Grade: TheraPure™
Nucleic Acid Type: RNA
Nucleoside Type: Uridine (U)
Product Type: 2in-Fluoro-U CEP
Purity: 98%
Quantity: 0.
5 g
Reagent Features: 2in-Fluoro modified
Reagent Type: Phosphoramidite
Shipping Condition: Room Temperature
Product Line: TheraPure™
Unit Size: Each