Thermo Fisher Chromatography Columns & Guard Cartridges (HPLC, UHPLC, GC)

Iright distributes a wide range of Thermo Fisher chromatography columns and accessories so you can choose one catalog page and outfit an entire workflow—HPLC/UHPLC, GC/GC-MS, IC, plus guard cartridges and holders. This collection page helps you compare chemistries, sizes, and use-cases quickly, then jump straight to representative SKUs for ordering or quotes.

About This Collection: Thermo Fisher Chromatography Columns & Cartridges

You’ll find a concise overview of column families (Hypersil GOLD, Accucore, Syncronis/Acclaim; TraceGOLD for GC; Dionex IonPac for IC) and how they map to common methods like LC-MS impurities, VOCs by GC-MS, or inorganic anions by IC. Iright can source variants across particle sizes, lengths, and internal diameters, and advise on guard/holder compatibility based on your instrument and matrix.

Product Subcategories at a Glance (HPLC/UHPLC, GC, IC, Guard Cartridges)

To make navigation simple, this page groups products into four buckets and surfaces the most searched chemistries first. Skim the category that matches your method, then use the Selection Guide to validate the exact spec you need.

HPLC & UHPLC Columns: C18, HILIC and Mixed-Mode Options

For small-molecule reversed-phase, Hypersil GOLD C18 is the workhorse—engineered for excellent peak shape and LC-MS friendliness across 1.9/3/5 µm formats. Accucore (core-shell) delivers high efficiency at lower backpressure for faster runs, while Syncronis emphasizes run-to-run reproducibility across particle sizes. For highly aqueous separations of polar analytes, the Hypersil GOLD aQ (polar-endcapped C18) is a practical first pick.

• When you want sharp peaks at LC-MS flow rates → Hypersil GOLD C18
• When you need speed/efficiency under moderate pressure → Accucore C18
• When method robustness is paramount → Syncronis C18
• When retention in high-water mobile phases matters → Hypersil GOLD aQ

GC Columns for GC/GC-MS: TraceGOLD TG-5MS, TG-624, WAX

GC methods often hinge on low bleed, inertness, and the right phase polarity. TraceGOLD TG-5MS (5% phenyl) is the general-purpose, low-bleed choice for GC-MS screening; TG-624 covers residual solvents and VOCs (EPA methods); TG-WaxMS supports polar compounds and FAMEs with thermal stability.

• Broad GC-MS screening → TG-5MS
• Residual solvents/VOCs → TG-624 / TG-624SilMS
• Polar volatiles & FAMEs → TG-WaxMS

Ion Chromatography (IC) Columns: Dionex IonPac Series

For anions and organic acids, IonPac AS11/AS11-HC are high-capacity workhorses designed for KOH gradients; the 4 µm packing updates improve resolution at the same selectivity. Capillary, 2 mm, and 4 mm formats let you fit flow requirements while keeping compatibility with standard suppressors.

• Screening of inorganic anions and organic acids → IonPac AS11-HC / AS11-HC-4 µm

• Choose 4 mm for conventional flows; 2 mm/capillary for solvent savings

Guard Cartridges & Holders: Protect Column Performance

Guard cartridges trap matrix particulates and strongly retained interferences so your analytical column lasts longer and stays reproducible. Thermo’s Uniguard™ holders connect directly to the column (1.0–4.6 mm IDs), and drop-in guard cartridges are available across Hypersil GOLD phases (packs of four) and Accucore.

• Match guard ID to the column ID; replace when pressure creeps or peak shape degrades
• For Hypersil GOLD aQ/HILIC/PFP etc., use the corresponding drop-in guard SKUs

Column Selection Guide: Choose by Chemistry, Application & Size

A quick map from sample to column type helps you narrow choices before you compare model-by-model. Use it as a first pass, then fine-tune ID/length and particle size (or film for GC) based on your instrument limits and target throughput.

Compare Thermo Fisher Columns: Chemistries, ID/Length, Use Cases

Before you dive into SKUs, this table summarizes what changes when you switch chemistries or formats. Use it to sanity-check whether you’re trading efficiency, robustness, or run time.

Representative SKUs & Specs (8–12 Models for Quick Ordering)

This curated list covers popular requests and high-intent searches. Use it as a starting shortlist; Iright can quote alternates (ID/length/particle) from the same families.

Methods & Applications: LC-MS, VOCs, Inorganic Ions & More

Your choice should reflect matrix, analyte polarity, and detector. For LC-MS impurity profiling, start with Hypersil GOLD C18 (2.1 mm ID, 1.9–3 µm) for peak shape and sensitivity; switch to aQ when highly aqueous conditions are required for polar retention.

For GC-MS general screening, TG-5MS is the backbone phase; choose TG-624 for residual solvents and VOCs or TG-WaxMS for polar volatiles and FAMEs. For inorganic anions and organic acids, IonPac AS11-HC with KOH gradients provides capacity and resolution across complex matrices.

FAQs: Column Choice, Guard Use, LC vs UHPLC, GC Low-Bleed

Before you add to cart, these quick answers can save time and re-runs. Each speaks to questions we see most from method development to routine QC.

Do guard cartridges change retention?
Minimal—good guards are short (e.g., 10 mm) and matched to column ID/phase; they primarily capture particulates and strongly retained junk. Replace when backpressure rises or peak tailing appears. 

When should I pick Accucore over fully porous?
When you want UHPLC-like efficiency at moderate pressures; core-shell designs often shorten runs without overstressing legacy pumps.

TG-5MS vs TG-624—how do I decide?
TG-5MS is a universal 5% phenyl for GC-MS screens; TG-624 (and TG-624SilMS) targets residual solvents/VOCs and aligns with common EPA methods.

What’s the default IC column for anions?
IonPac AS11-HC remains a standard for inorganic anions and organic acids; the 4 µm version increases resolution without changing selectivity.

Can I swap LC and UHPLC formats?
Yes, but match particle size and ID to your system’s pressure limits; moving from 5 µm/4.6 mm to 1.9–3 µm/2.1 mm may exceed pump or detector constraints.

Which holder fits my guard cartridge?
Use Uniguard holders: 851-00 (1.0 mm), 852-00 (2.1–3.0 mm), 850-00 (4.0–4.6 mm), matched to your column ID.

Get a Quote from Iright or Ask for Column Matching

Tell us your target analytes, instrument, and constraints (matrix, pH, pressure, max temp). Iright will confirm the optimal Thermo Fisher SKU (or alternates in the same family), bundle the correct guard and Uniguard holder, and provide lead time and pricing—so you can move from trial to validated method faster.