Thermo Fisher Chromatography Systems: HPLC/UHPLC, IC & GC Solutions

You want a single place to understand Thermo Fisher’s chromatography systems and decide what fits your samples, methods, and compliance needs. This collection introduces each platform at a glance and routes you to products, accessories, and expert support from Iright, an authorized distributor with broad Thermo Fisher coverage.

What Thermo Fisher Chromatography Systems Cover: HPLC/UHPLC, IC & GC

Before you compare individual models, it helps to frame chromatography as a complete system—pump, autosampler, detector, controller, and software. Thermo Fisher offers three complementary routes: HPLC/UHPLC for organic analytes, ion chromatography (IC) for ionic species, and gas chromatography (GC) for volatile compounds.

Thermo Fisher chromatography systems are engineered to deliver reproducible flow control, robust injection precision, and detector stability for both research and regulated QC. You can run routine assays confidently or push sensitivity through MS coupling, all inside a data-integrity-ready environment with Chromeleon CDS oversight.

Vanquish HPLC/UHPLC, Dionex ICS-6000 IC, and TRACE GC — Product Families

To shorten your selection process, start from the family that aligns with chemistry and matrix. Each family scales from method development to high-throughput routine analysis, with field-proven hardware and software integrations.

• Vanquish™ HPLC/UHPLC – High-pressure capability, low dispersion, and excellent retention-time stability for small molecules, peptides, and biomolecules. Broad detector options (UV/Vis, fluorescence, charged aerosol, MS coupling) support method transfer and lifecycle management.

• Dionex™ ICS-6000 HPIC – Modular ion chromatography for anions, cations, amines, organic acids, and conductivity-based workflows. Capillary and standard-bore configurations minimize eluent use while enabling gradient separations and IC-MS coupling when required.

• TRACE™ 1300/1310 GC – Modular gas chromatography platform designed for routine, regulated environments. Detector and inlet options cover residual solvents, VOCs, petrochemical components, flavors and fragrances, and other volatile targets, with straightforward maintenance.

How to Choose: HPLC vs IC vs GC by Sample, Analyte and Workflow

A good starting point is your primary analyte class and matrix complexity. The quick matrix below maps common scenarios to a preferred route, so you can narrow to a family and then fine-tune detectors, flow paths, and accessories.

Featured Chromatography Systems & Popular Configurations

Choosing a system usually means choosing a configuration (flow path, detector set, autosampler capacity, and control). Because Thermo Fisher systems are built-to-order and configuration codes vary by region and options, featured items below highlight representative configurations you can discuss with Iright. After we confirm your exact method and compliance needs, we’ll provide the official Thermo Fisher configuration code(s) on your quote.

• Vanquish UHPLC – Method Development Bundle
  Designed for gradient method scouting with low dispersion plumbing and dual-detector readiness; ideal for transferring validated methods to production with minimal rework.
  Good for: impurity profiling, stability studies, and robust retention-time precision.

• Dionex ICS-6000 – Environmental IC Kit
  A conductivity-based system with electrolytic suppression and eluent generation to simplify anion analysis in drinking water labs.
  Good for: routine IC with minimal manual eluent prep and strong day-to-day reproducibility.

• TRACE 1310 GC – Residual Solvent Package
  Single-quad GC configuration tuned for pharmacopeial residual solvent methods, with easy inlet maintenance and reliable autosampler operation.
  Good for: GMP QC labs running validated methods and batch throughput.

Complete the Workflow: Chromeleon CDS, Columns, Vials & GC/IC Accessories

Chromatography performance depends on more than a pump and detector. Building your workflow with the right software and accessories helps you meet data integrity, uptime, and cost-per-run targets without surprises.

Chromeleon™ CDS centralizes instrument control (LC/IC/GC and MS), audit trails, and compliant reporting so your methods survive from development to validation and routine QC. For hardware continuity, pair Vanquish with the appropriate columns (e.g., sub-2-µm for UHPLC), ICS-6000 with the correct suppressors and electrolytic eluent generation, and TRACE with inlet liners, septa, and columns matching your solvent and temperature program. Iright can package columns, vials, caps, syringes, and essential spares alongside your system so your lab is productive on day one.

Recommended add-ons to consider (checklist):

• Chromeleon CDS licenses and user packs for your site

• UHPLC/HPLC columns by chemistry (C18, HILIC, ion-pair, size exclusion)

• IC suppressors and eluent generation consumables

• GC columns matched to solvents/targets, inlet liners, septa, ferrules

• Autosampler vials, caps, and plates compatible with your trays

• Qualification/validation services and PQ/OQ documentation

Proven Workflows: Pharma QC, Environmental IC, and Residual Solvents by GC

Now map systems and accessories to real-world methods. The snapshots below show how you can meet regulations or internal SLAs while controlling risk, cost, and change-control overhead.

Pharmaceutical QC (HPLC/UHPLC)
You can validate impurity methods on Vanquish using UV or CAD, then extend sensitivity with LC-MS as needed. Tight gradient precision and thermal control minimize retention shifts, easing method transfer from R&D to GMP. Chromeleon enforces audit trails and electronic signatures for data integrity reviews.

Environmental & Water Testing (IC)
For routine anions in drinking water, an ICS-6000 with suppressed conductivity simplifies operations and reduces manual eluent prep via electrolytic eluent generation. Low carryover and capillary options lower per-sample costs while keeping detection limits predictable for compliance work.

Residual Solvents / Volatile Organics (GC)
A TRACE 1310 system with FID or GC-MS handles USP/EP residual solvent panels and broader VOC suites. Tool-less inlet parts and well-documented SOPs shorten downtime. Where confirmatory identification is needed, GC-MS coupling tightens specificity without tearing up validated workflows.

Chromatography Systems FAQs: HPLC/UHPLC vs GC, When to Choose IC, and More

The right platform is the one that matches your analytes, matrix, and compliance workload. These quick answers cover the questions we hear most and help you frame your next step with Iright.

1. What is the practical difference between HPLC and UHPLC?

Both separate nonvolatile analytes in liquids. UHPLC uses smaller particles and higher pressures for faster runs and higher efficiency, which improves peak capacity and can cut cycle times in busy QC labs.

2. When is ion chromatography preferable to HPLC?

If your targets are inorganic ions or small polar ionic species in aqueous matrices, IC with suppressed conductivity is often simpler, more selective, and more sensitive than HPLC with indirect detection.

3. Why choose GC for residual solvents or VOCs?

Volatile analytes vaporize cleanly and elute in the gas phase with excellent resolution. GC detectors such as FID offer stable quantitation for routine panels; GC-MS adds selectivity when interferences are a concern.

4. Can I add MS later?

Yes. Many Vanquish and TRACE configurations are MS-ready, and ICS-6000 supports IC-MS for specific workflows. Plan plumbing, interfaces, and software licenses early to smooth the path for future upgrades.

5. How does Chromeleon CDS support compliance?

It unifies instrument control and data handling with audit trails, permissions, and electronic signatures, supporting ALCOA+ principles and routine data integrity reviews.

6. What services does Iright provide with the system?

We help with method review, configuration, quotation, installation coordination, and accessory bundling. If you’re transferring a validated method, we align components to minimize requalification.

Talk to Iright: Request a System Recommendation, Specs, and a Fast Quote

To get a precise configuration and verified Thermo Fisher SKU codes, share your matrix, target analytes, LOD/LOQ, detector preference, required standards (e.g., USP/EP, EPA), and expected weekly throughput. Iright will return a tailored recommendation, itemized quote with official codes, and an accessory list so you can order once and run confidently.