Agilent, 681975-908, AdvanceBio HIC, 4.6 × 30 mm, 3.5 µm

AdvanceBio HIC, 4.6 × 30 mm, 3.5 µm. These hydrophobic interaction chromatography columns are based on fully porous ZORBAX particles and are designed for native mode separations of proteins, mAbs, and ADCs based on hydrophobicity

Specifications:
Brand: AdvanceBio HIC
Hardware: SS
Inner Diameter (ID): 4.6 mm
LC Platform: Stainless Steel
Length: 30 mm
Maximum Temperature: 60 °C
Particle Size: 3.5 µm
Particle Type: Fully Porous
Pore Size: 450 Å
Pressure Rating: 400 bar
Separation Mode: Hydrophobic Interaction (HIC)
Shipping Solvent: Acetonitrile
UNSPSC Code: 41115709
pH Range: 2-8

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The AdvanceBio HIC column, featuring dimensions of 4.6 × 30 mm and a 3.5 µm particle size, is specifically engineered for high-performance hydrophobic interaction chromatography of biomolecules. Optimized for the separation and characterization of monoclonal antibodies, antibody-drug conjugates, and other therapeutic proteins, this column delivers excellent resolution and reproducibility for both qualitative and quantitative analyses. Its robust silica-based stationary phase ensures stable retention times and consistent peak shapes, even under demanding analytical conditions.

Ideal for workflows in biopharmaceutical research, process development, and quality control, the column supports high-throughput analysis with efficient protein recovery. Typical applications include variant analysis, aggregation studies, and impurity profiling, making it valuable for method development and comparability studies in regulated environments.

The column is compatible with a wide range of Agilent liquid chromatography systems, including 1200 Infinity Series and 1290 Infinity II platforms, and integrates seamlessly with other AdvanceBio columns, supporting flexible multi-dimensional analyses. Designed for ease of use and reliable performance, this column offers biopharma laboratories a powerful tool for advancing protein characterization and analytical workflows, enabling confident decision-making throughout the development cycle.