Agilent, 793775-944, AdvanceBio RP-mAb Diphenyl, 2.1 x 150 mm, 3.5 µm

AdvanceBio RP-mAb Diphenyl, 2.1 x 150 mm, 3.5 µm. A reversed-phase diphenyl HPLC column with superficially porous particles and a wide (450 Å) pore size designed for mAbs and other larger proteins when alternate selectivity is needed or preferred.

Specifications:
Brand: AdvanceBio RP mAb Diphenyl
Hardware: SS
Inner Diameter (ID): 2.1 mm
LC Platform: Stainless Steel
Length: 150 mm
Maximum Temperature: 90 °C
Part Number Application Domain: Biopharma
Part Number Application: Intact & Subunit AnalysisMonoclonal Antibodies (mABs)Proteins
Particle Size: 3.5 µm
Particle Type: Superficially Porous
Phase: Diphenyl
Pore Size: 450 Å
Pressure Rating: 600 bar
Separation Mode: Reversed Phase
Shipping Solvent: Acetonitrile/Water
Technique: LCLC & LC/MS
UNSPSC Code: 41115711
pH Range: 1-8

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The Agilent AdvanceBio RP-mAb Diphenyl column offers precise and robust reverse phase separation for monoclonal antibodies and related biologics. With a 2.1 x 150 mm dimension and 3.5 micrometer particle size, this column provides optimal peak resolution, high efficiency, and excellent reproducibility for intact and fragmented antibody analysis. Its diphenyl stationary phase enhances selectivity and separation of closely related protein variants, making it ideal for critical quality attribute assessment during biopharmaceutical development and manufacturing.

Engineered for compatibility with UHPLC and HPLC systems, including Agilent InfinityLab and 1290 Infinity II series, this column supports applications such as purity analysis, stability testing, and detailed characterization of mAbs and protein therapeutics. Its robust performance reduces sample carryover and minimizes column degradation, ensuring consistent results even with complex biological matrices. The column is fully compatible with a wide range of organic modifiers and mobile phases routinely used in reverse phase protein separations.

Paired with Agilent AdvanceBio sample preparation products and detection solutions, this column streamlines workflows for bioprocess monitoring and research environments. It is an essential tool for analytical laboratories engaged in protein drug discovery, process development, and quality control of therapeutic antibodies and related biologics.