Agilent, 795775-944, AdvanceBio RP-mAb Diphenyl, 2.1 x 100 mm, 3.5 µm

AdvanceBio RP-mAb Diphenyl, 2.1 x 100 mm, 3.5 µm. A reversed-phase diphenyl HPLC column with superficially porous particles and a wide (450 Å) pore size designed for mAbs and other larger proteins when alternate selectivity is needed or preferred.

Specifications:
Brand: AdvanceBio RP mAb Diphenyl
Hardware: SS
Inner Diameter (ID): 2.1 mm
LC Platform: Stainless Steel
Length: 100 mm
Maximum Temperature: 90 °C
Part Number Application Domain: Biopharma
Part Number Application: Intact & Subunit AnalysisMonoclonal Antibodies (mABs)Proteins
Particle Size: 3.5 µm
Particle Type: Superficially Porous
Phase: Diphenyl
Pore Size: 450 Å
Pressure Rating: 600 bar
Separation Mode: Reversed Phase
Shipping Solvent: Acetonitrile/Water
Technique: LCLC & LC/MS
UNSPSC Code: 41115711
pH Range: 1-8

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Agilent’s AdvanceBio RP-mAb Diphenyl column delivers high-resolution reversed-phase separations optimized for monoclonal antibody (mAb) analysis. Featuring a 2.1 x 100 mm format with a 3.5 micron particle size, this column is engineered for precise characterization of intact antibodies, fragments, and related protein therapeutics. The diphenyl bonding chemistry provides unique selectivity, enabling efficient resolution of closely related protein forms, including variants and impurities that are critical in biopharmaceutical development.

Ideal for use in both method development and routine quality control, the column supports robust performance in analytical workflows involving stability testing, charge variant analysis, and batch-to-batch comparability studies. It is fully compatible with UHPLC and HPLC systems from Agilent and most major manufacturers, ensuring seamless integration into existing laboratories.

The AdvanceBio RP-mAb Diphenyl column is part of Agilent’s comprehensive AdvanceBio portfolio, making it suitable for pairing with additional bioseparation tools designed for mAb, ADC, and protein analysis. Typical applications include detailed analysis of therapeutic mAbs, biosimilars, antibody-drug conjugates, and other large biomolecules in pharmaceutical research, development, and quality assurance environments.