Agilent, PL1580-3325, AdvanceBio SEC 500 Å, 2.7 µm, 4.6x150mm

AdvanceBio SEC 500 Å, 2.7 µm, 4.6x150mm. A size exclusion column for aggregate analysis of large biological molecules such as AAVs, VLPs, and large oligonucleotides.

Specifications:
Brand: AdvanceBio SEC
Guard Column: No
Hardware: SS
Inner Diameter (ID): 4.6 mm
Length: 150 mm
Maximum Temperature: 80 °C
Molecular Weight Lower Limit: 5000 Da
Molecular Weight Upper Limit: 5 MDa
Particle Size: 2.7 µm
Particle Type: Fully Porous
Phase: SEC
Pore Size: 500 Å
Pressure Rating: 400 bar
Separation Mode: SFC
Shipping Solvent: Phosphate Buffer/0.02% Sodium azide
Storage Temp Conditions: Store at ambient temperature
pH Range: 2-8.5

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The AdvanceBio SEC 500 Å, 2.7 µm, 4.6x150mm column is engineered for high-resolution size exclusion chromatography, ideal for detailed analysis of biotherapeutics such as monoclonal antibodies, protein aggregates, and biosimilars. Utilizing advanced silica particle technology, this column delivers superior precision and consistent results when separating molecules based on size, minimizing sample interaction and nonspecific binding. The 500 Å pore size facilitates optimal separation of proteins and peptides across a broad molecular weight range, supporting critical applications like aggregate quantification, stability studies, and routine quality control.

Suitable for both research and regulated environments, this column ensures rapid analysis with exceptional reproducibility and robustness. It is fully compatible with Agilent 1260 Infinity II and 1290 Infinity LC systems, as well as major HPLC and UHPLC platforms, integrating seamlessly into existing workflows. The column is also optimized for use with AdvanceBio SEC mobile phases to maximize performance. Researchers in biopharmaceutical development, quality assurance, and process optimization benefit from its reliability in detecting size variants and monitoring product purity. This product is supported by Agilent’s comprehensive suite of AdvanceBio columns and resources for biomolecule characterization.