Cytiva, 7008601, Stax™ disposable depth filter systems

Stax Capsule, HP-Series, PDP8 media, 0.5 m² EFA Stax™ disposable depth filter systems, a Pall Life Sciences product, is a highly versatile disposable depth filter platform that is well suited for demanding prefiltration and clarification applications in biopharmaceutical workflows. This ready-to-use platform streamlines your process filtration applications. Stax™ disposable depth filter capsules increase process efficiencies and address the needs for simplicity, safety, speed, and intuitive operation. • Low hold-up volume Greater product recovery and lower post use rinse volume requirements than traditional modules and housings.
Post use blow down in forward or reverse flow direction are possible. • Seamless linear scalability Greater flexibility and assurance of process success from <1L to 20,000+ L. Scalable through our entire line of scale-up devices (SupraCap™ 50 and SupraCap™ 100 capsules) as well as traditional Supradisc I and Supradisc II modules. • Minimized risk The Stax™ capsules are based upon the outstanding design of the Supradisc II modules, which provides benefits in process stability due to their high mechanical robustness. • No housings Easier to use and manipulate while eliminating operator safety issues. • Completely disposable Eliminates need for cleaning and cleaning validation. • Encapsulated design Reduces operator exposure to potential biohazards. • Intuitive operation Reduces operator training and increases time to acceptance. • Small footprint Enables use in close proximity to other equipment and reduces cost to install. • Serial filtration capability Utilising Stax™ capsules containing different media grades in one chassis improves the flexibility and economy of operating the Stax™ platform. Capsule and Chassis Design With three interchangeable capsule sizes ranging from 0.25 m 2 to 2.0 m 2 (2.70 ft 2 to 21.5 ft 2 ), Stax™ capsules permit incremental increases in process fluid volume and filter area using this modular design. Stax™ system chassis are designed for assembly and use by a single operator and provide a logically conceived disposable platform in which the operator can load, operate and unload in an ergonomically designed vertical orientation. Stax™ mAx Clarification Platform The ability to operate with two different media grades in one chassis (serial filtration) further improves the flexibility and economy of operating the Stax™ platform. For the clarification of mAb cell cultures we recommend using the Stax™ mAx clarification platform. It is a two-stage clarification process combining two Stax™ capsules with HP-series filter media (PDP8 and PDE2). It provides a consistent filtrate quality ready for 0.2 µm filtration and is less sensitive to upstream variations. Stax CF cake filtration capsules Stax™ CF Cake Filtration is used for robustly harvesting high density cell cultures and/or high turbidities, in particular when utilizing filter aids such as diatomaceous earth (DE) or activated carbon powder. Filter media The Pall Stax™ capsules are available in a wide array of advanced pharmaceutical-grade Seitz™ depth filter media. Supported through comprehensive validation guides, Seitz™ depth filter media meets the highest pharmaceutical standards for: Quality Lot-to-lot consistency Manufacturing control Low extractable content Low endotoxin content P-series Seitz™ P-series depth filter sheets were specifically developed for the strict requirements in biotechnological and pharmaceutical industries. Manufactured with stringent in-process control methods assures consistent filtration quality, a very high purity of filter medium, and alignment with the requirements of the pharmaceutical industry. HP-series Seitz™ HP-series depth filter sheets are comprised of two distinct layers of Seitz™ P-series depth filter sheets; a coarser layer upstream followed by a finer layer downstream. These performance-enhanced depth filter sheets have been designed for use in low viability, high solids containing applications. As small shifts in process conditions can cause dramatic differences in filtration requirements, the flexibility of combining any combination of P-series media in an HP format allows for improved process optimization. Bio-series Seitz™ Bio-series depth filter sheets are specially developed from highly purified natural and modified cellulose fibers and contain no inorganic materials such as diatomaceous earth (DE), perlite or glass fibers. The lack of these inorganic substances significantly reduces the levels of ash and heavy metal extractables. Flexibility in Process Design The Stax™ platform has been designed to accommodate nearly all processing options. Whether you want to process: Bottom up Top down Bottom in/bottom out In series Simply using the uniquely designed manifold kits provides complete flexibility in your process design. Appropriate for use in primary and secondary filtration steps, as well as post-precipitation clarification, in applications such as: Mammalian cell cultures Yeast E.coli lyates and refolds Vaccines Blood plasma and serum media