Thermo Fisher, 22309, GMBS (N-γ-maleimidobutyryl-oxysuccinimide ester)

GMBS (N-γ-maleimidobutyryl-oxysuccinimide ester) Thermo Scientific Pierce GMBS is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a short spacer arm (7.
3 angstroms).
Features of GMBS:
•Reactive groups:NHS esterandmaleimide
•Reactive toward: amino and sulfhydryl groups
• C4-homolog of aliphatic spacer series which includesAMAS,BMPS, GMBS andEMCS
• NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
• Maleimides react with -SH groups at pH 6.
5-7.
5, forming stable thioether linkages
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO); compare toSulfo-GMBS
• Short aliphatic spacer has low potential for eliciting an immune responseProduct References:Crosslinker Application Guide -- search for recent literature references for this productCell Permeability: Yes
Description: GMBS
Form: Powder
Labeling Method: Chemical Labeling
Molecular Weight (g/mol): 280.
23
PEGylated: No
Product Line: Pierce™
Quantity: 50 mg
Reactive Moiety: Maleimide, NHS Ester
Shipping Condition: Ambient
Solubility: DMF, DMSO
Spacer Arm Length: 7.
3 Å
Water Soluble: No
Chemical Reactivity: Amine-Sulfhydryl
Cleavable: No
Crosslinker Type: Heterobifunctional
Format: Standard
Product Type: Crosslinker
Spacer: Short (<10 Å)
Unit Size: Each