Thermo Fisher, GM1108G, Human OCT1 (G) SLC Transporter Cells

Human OCT1 (G) SLC Transporter Cells TRANSiPORT Human OCT1 (G) SLC Transporter Cells are HEK293 cells that transiently overexpress the OCT1 solute carrier (SLC) transport protein. Solute carriers are a super-family of membrane transporters that can affect pharmacokinetics and drug exposure by governing the transport of solutes in and out of cells. The OCT1 SLC transporter protein is found in hepatocytes.
• Assess potential for transporter-mediated drug metabolism
• Easy to use format
• Obtain high quality results with a large signal-to-noise ratioChoice of measurement systemCell-based assays can be performed using radioisotope-labeled compounds, fluorescence-labeled compounds, or non-labeled compounds. The amount of substrate transported into the cells can be measured directly using a liquid scintillation counter, fluorescence plate reader, or LC-MS/MS, thereby allowing direct evaluation of SLC transporter activity.
Assay reliabilityMock HEK293 cells (Cat. No. GM1101G) that do not overexpress the SLC transporter are available for use as a negative experimental control. Some compounds may demonstrate high background levels of transport due to the presence of endogenous transporters or non-specific binding.
Rapid resultsThe convenient product format enables data generation in 2 days from thawing of the cells to final results.
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Product Type: SLC Transporter Cell
Quantity: 8–10M cells
Cell Line: 293 (HEK)
Culture Type: Mammalian Cell Culture
Species: Human
Unit Size: Each