Waters, 186005351, ACQUITY UPLC CSH Fluoro-Phenyl Column, 130Å, 1.7 µm, 2.1 mm X 50 mm, 1/pk

Designed to maximize selectivity differences, the ACQUITY CSH Fluoro-Phenyl column provides maximum method development freedom, especially when using low pH mobile phases. The non-encapped sorbent provides you with enhanced retention of acidic compounds.

Specifications
Chemistry: PFP/Fluoro-Phenyl
Separation Mode: Reversed Phase
Particle Substrate: Hybrid
pH Range Min: 1 pH
pH Range Max: 8 pH
Maximum Pressure: 18000 psi (1240 Bar)
Endcapped: No
Bonding Technology: Fluoro-Phenyl
Silanol Activity: Low
Particle Shape: Spherical
Particle Size: 1.7 µm
Endfitting Type: Parker-style
Pore Size: 130 Å
Format: Column
Surface Area: 185
System: UPLC, UHPLC
Particle Technology: CSH
USP Classification: L43
Inner Diameter: 2.1 mm
Length: 50 mm
Carbon Load: 10 %
eCord: Yes
UNSPSC: 41115709
Brand: ACQUITY UPLC
Product Type: Columns
Units per Package: 1 pk

Additional Information
ACQUITY UPLC CSH Fluoro-Phenyl Column, 130Å, 1.7 µm, 2.1 mm X 50 mm, 1/pk With an intricate combination of multiple retention mechanisms, the ACQUITY UPLC CSH Fluoro-Phenyl Column provides exceptional selectivity for positional isomers, halogenated compounds, and polar compounds. These retention mechanisms include dipole-dipole, hydrogen-bonding, aromatic (pi-pi), and hydrophobic interactions. Compared to the lab equipment used with traditional PFP-bonded stationary phases, the unique surface chemistry of the Charged Surface Hybrid (CSH) particle provides enhanced retention of acidic compounds. CSH Technology is Waters’ third-generation hybrid particle technology, based on Ethylene Bridged Hybrid particle technology (BEH) and incorporating a low-level surface charge designed to improve sample loadability and peak asymmetry in low-ionic-strength mobile phases. This is achieved while maintaining the mechanical and chemical stability inherent in the BEH particle technology. This allows ACQUITY UPLC CSH Fluoro-Phenyl Columns to offer superior peak shape for basic compounds, increased loading capacity, rapid column equilibration, improved reproducibility, and exceptional stability at both low and high pH. All ACQUITY UPLC CSH packing materials are designed for use with the ACQUITY UPLC systems and are manufactured in cGMP, ISO 9001 certified manufacturing facilities with the use of ultrapure reagents. Each batch of material is chromatographically tested with acidic, basic, and neutral analytes, and results are held to narrow specification ranges, allowing Waters to ensure excellent and reproducible performance. Further testing can be performed using Neutrals QC Reference Material . This column is sold one per package with an inner diameter of 2.1 mm and a length of 50 mm and includes eCord Intelligent Chip technology for tracking the column’s performance history. All columns are shipped in 100% acetonitrile.

FAQ
What Are Some Use Cases For ACQUITY UPLC CSH Fluoro-Phenyl Columns? One of the most frequently prescribed medications in modern medicine, antibiotics are used to treat bacterial infections by inhibiting cell-wall synthesis of bacterial organisms. These columns successfully retain and separate Beta-lactam antibiotics in a rapid analysis time.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant that affects chemicals in the brain that may become imbalanced. This can be used to treat depression, obsessive-compulsive disorder, anxiety, and other mood disorders. The unique selectivity of ACUITY UPLC CSH Fluoro-Phenyl columns allows for successful resolution of cis- and trans- isomers of paroxetine.