Corning Bioprocess Adherent Solutions: HYPERStack • CellSTACK • CellCube • Ascent FBR

Corning Bioprocess Adherent solutions are purpose-built for the scalable expansion of anchorage-dependent cells, including mesenchymal stem cells (MSCs), Vero, HEK293, and other commonly used lines in cell therapy and vaccine production. Designed for applications such as cell therapy manufacturing, viral vector production, and vaccine development, this product line offers advanced vessels and closed-system platforms that deliver high surface area, reliable gas exchange, and consistent, GMP-compatible performance. Corning’s innovative engineering helps streamline large-scale adherent cell culture workflows, supporting both research and commercial bioprocessing needs.

Platform Line‑up: Choosing the Right Corning Bioprocess Adherent System

Corning Bioprocess Adherent solutions include a comprehensive range of scalable platforms designed for efficient adherent cell culture. Each system offers unique features and advantages, supporting the requirements of cell therapy manufacturing, vaccine production, and large-scale bioprocessing. Below is a quick selection guide to help users identify the best platform for their specific applications.

Technical Specifications: Comparing Corning Adherent Bioprocess Platforms

Corning Bioprocess Adherent solutions deliver flexible options for high-yield adherent cell culture, with each platform tailored for scalability, process control, and automation. Below are the core technical specifications and comparison highlights to guide optimal selection for diverse bioprocessing needs.

These platforms ensure consistent, scalable, and contamination-minimized adherent cell culture for research and commercial bioproduction.

Scalable Adherent Cell Culture for Cell Therapy, Vaccines, and Biomanufacturing

Corning Bioprocess Adherent platforms are widely used across the life sciences and biomanufacturing sectors, delivering reliable, high-yield expansion of anchorage-dependent cells for a range of critical applications. By supporting scalable and closed-system adherent cell culture, these solutions enable consistent results in both research and GMP production environments.

Typical Application Scenarios:

• Cell Therapy Manufacturing
  Large-scale expansion of mesenchymal stem cells (MSCs), CAR-T cells, and other therapeutic cell types for clinical and commercial therapies.
• Vaccine Production
  Efficient growth of Vero, HEK293, and other cell lines for the production of viral vaccines and recombinant proteins.
• Viral Vector Manufacturing
  Scalable production of lentivirus, adenovirus, and AAV vectors is essential for gene therapy and vaccine platforms.
• Extracellular Vesicle (EV) and Exosome Harvesting
  Consistent, high-throughput expansion for research and therapeutic applications involving exosomes and extracellular vesicles.
• Industrial Cell Expansion
  Reliable cell scale-up to support large-batch biomanufacturing, biosimilar development, and protein expression.

Corning’s Bioprocess Adherent solutions ensure robust performance in demanding workflows, supporting the future of cell and gene therapy, vaccine innovation, and advanced bioprocessing.

Innovative Advantages: Gas-Permeable Technology, Automation, and Closed-System Adherent Cell Culture

Corning Bioprocess Adherent platforms are engineered with industry-leading innovations to optimize performance, streamline workflows, and ensure consistent, high-yield adherent cell culture at every scale.

Corning’s ongoing innovation in adherent cell culture technology empowers bioprocessing teams to achieve reliable, scalable, and compliant results across all production phases.

FAQ & Selection Guide: Choosing the Right Corning Bioprocess Adherent 

1. Which Corning Bioprocess Adherent platform is best suited for my cell type?

Platform selection depends on the cell type and production scale. For large-scale expansion of adherent cell lines such as MSCs, HEK293, or Vero, HYPERStack and CellSTACK vessels provide high surface area and robust performance. CellCube is recommended for applications requiring modular perfusion and high-throughput production. The Ascent Fixed Bed Bioreactor is ideal for closed-system, automated workflows and GMP manufacturing of sensitive or therapeutic cells.

2. How can I scale up my adherent cell culture process from R&D to GMP manufacturing?

Corning’s Bioprocess Adherent solutions offer modular and scalable designs, enabling users to start with small-scale research platforms and transition seamlessly to commercial production. Systems like CellSTACK and HYPERStack support batch size increases without changing core processes, while the Ascent FBR enables automated, closed-system scale-up compatible with GMP requirements.

3. What is the typical cell culture capacity per unit for each platform?

Capacity varies by system and configuration:

• HYPERStack: Up to 18,000 cm² per vessel
• CellSTACK: Up to 25,440 cm² per vessel (40-layer format)
• CellCube: Ranges from 8,500 cm² (single module) to 850,000 cm² (multi-module)
• Ascent FBR: Up to 2.52 m² (25,200 cm²) per bioreactor

These scalable surface areas allow users to select the optimal platform based on production goals and cell type requirements.

Accessory & Consumable Recommendations

To maximize performance and streamline workflows, Corning offers a full portfolio of accessories and consumables compatible with its Bioprocess Adherent platforms. These products help ensure sterility, process efficiency, and reliable cell expansion across both research and manufacturing environments.

Recommended Accessories and Consumables:

Cell Expansion Bags
Closed-system bags designed for aseptic cell expansion, media preparation, and transfer processes.

Tubing Kits and Aseptic Connectors
Pre-sterilized tubing sets and sterile connectors support secure, contamination-free fluid handling and closed-system integration.

Microcarriers
High-quality, surface-treated microcarriers enhance cell attachment and yield for specific adherent cell types.

Cryopreservation Bags and Vials
Solutions for safe, scalable freezing and storage of harvested cells to preserve viability.

Single-Use Bottles, Flasks, and Reservoirs
Flexible options for reagent storage, sampling, and process scale-up in closed systems.

Selecting the right accessories and consumables is essential for achieving optimal results in adherent cell culture and large-scale bioprocessing.

Related Collections

Assay
For downstream cell-based assays, screening, and analytical workflows.

Storage
For cryopreservation and secure storage of expanded adherent cell populations.

Genomics
For molecular analysis, nucleic acid extraction, and gene expression studies using cultured cells.

MCTs
For sample handling and centrifugation steps during cell harvest and downstream processing.