Cytiva Oligonucleotide Synthesis & Purification Solutions

Discover how Cytiva makes oligonucleotide synthesis and purification simple and reliable, whether you’re working at the research bench or producing at scale. With advanced solutions for both DNA and RNA synthesis, as well as efficient purification workflows, Cytiva helps you achieve high-purity results you can trust—every time.

Our technologies are built to support you through every step of the oligo manufacturing process, offering the purity, scalability, and compliance needed for today’s scientific and industrial demands. Chosen by labs and manufacturers around the world, Cytiva’s products give you the flexibility and performance to drive breakthroughs in diagnostics, therapeutics, and genomics.

Explore Cytiva Oligonucleotide Synthesis & Purification Product Range

To support every stage of your oligonucleotide workflow, Cytiva offers a curated selection of specialized products tailored for DNA and RNA synthesis, purification, and process scale-up. Explore the unique features and application focus of each product type to find the optimal solution for your research or manufacturing needs.

Chromatography Resins & Media

Core parameters: Particle sizes from 15–90 μm; high binding capacity; scalable from lab to production.
Key advantages: Superior purity, high throughput, GMP compliance, easy scale-up.
Typical applications: Ion exchange and reversed-phase purification of DNA/RNA oligonucleotides for research, clinical, and GMP production.

Oligonucleotide Synthesis Columns

Core parameters: Optimized flow rates; robust construction; broad compatibility with synthesizers.
Key advantages: Consistent synthesis efficiency, minimized carryover, high reproducibility.
Typical applications: Automated DNA/RNA synthesis in laboratories and pilot production.

Prepacked Columns

Core parameters: Ready-to-use; filled with industry-leading chromatography resins; available in various sizes.
Key advantages: Convenient setup, reduced validation time, reproducible results, scalable for process development and manufacturing.
Typical applications: Fast purification of oligonucleotides in research, process development, and GMP environments.

Purification Reagents & Consumables

Core parameters: High-purity reagents; compatible with leading synthesis and purification platforms.
Key advantages: Reliable performance, reduced contaminants, streamlined workflows.
Typical applications: Oligonucleotide desalting, deprotection, and polishing steps for both laboratory and industrial production.

No matter your scale or application, Cytiva’s oligonucleotide synthesis and purification solutions help ensure efficiency, quality, and compliance at every step.

Why Choose Cytiva for Oligonucleotide Synthesis and Purification?

Selecting the right partner is critical when your goals are efficiency, compliance, and consistent oligo quality. Cytiva stands out for its relentless focus on scientific innovation and operational excellence in oligonucleotide synthesis and purification.

Our proprietary high-capacity chromatography media and precision purification technologies are the result of continuous research and close collaboration with leading scientists. These innovations enable not just higher yields and purity, but also reliable performance across automated and scalable production environments.

As a global industry leader, Cytiva is recognized for its commitment to quality and regulatory compliance. All solutions meet stringent GMP and ISO standards, supporting seamless transitions from development to commercial manufacturing. Our established global supply chain, responsive technical support, and customer-centric service ensure you have a dependable partner at every stage.

With Cytiva, you gain more than advanced products—you access a network of expertise, industry trust, and ongoing support to empower your scientific breakthroughs and business growth.

Oligonucleotide Product Selection Guide & Classic SKUs

Selecting the right chromatography media, synthesis column, or purification reagent ensures optimal yield, purity, and cost efficiency. The table below matches common application scenarios with Cytiva’s validated SKUs, guiding you through flexible options suitable for lab-scale research up to industrial GMP production.

Product Selection Table

Application Scenario	Recommended Product Type	Key Parameters	Why Choose This Product
Lab-scale DNA/RNA synthesis	Synthesis Columns	Stainless steel, optimized flow, 1–5 mL	Excellent reproducibility for research and pilot batches
Lab-scale oligonucleotide purification	MicroSpin G‑50 DNA Grade Column	Sephadex G‑50 resin, 12–50 µL volume	Fast desalting and dye removal post-synthesis
Medium-scale purification	HiPrep 26/10 Desalting Column	Sephadex G‑25 resin, 53 mL bed	Convenient buffer exchange ≥15 mL, ÄKTA compatible
Large-scale/GMP production	Capto Q Chromatography Resin	Strong anion exchange, 90 µm particle	High binding capacity, scalable, GMP-ready

Classic SKUs for Key Oligonucleotide Workflows

SKU	Product Name	Application Scale	Key Specs
27‑5330‑02	MicroSpin G‑50 DNA Grade Column	Lab-scale purification	Sephadex G‑50, 12–50 µL bed volume
17‑5087‑01	HiPrep 26/10 Desalting Column	Medium-scale purification	53 mL Sephadex G‑25 bed, up to 15 mL sample
17‑5316‑10	Capto Q Chromatography Resin (25 mL)	Large-scale production	90 µm particles, strong ion exchange
17‑5055‑01	HiTrap DEAE Sepharose FF, 1 mL prepacked	Pilot/medium-scale work	Weak anion exchanger, 5 mL column volume

By matching product characteristics to your synthesis scale, desired purity, and workflow compatibility, Cytiva lets you quickly build a customized solution—from micro‑volume research to full‑scale GMP manufacturing. Next, explore our FAQ section for practical guidance and expert insights.

Oligonucleotide Synthesis & Purification FAQs

1. How can I improve the purity of synthesized oligonucleotides?

Use optimized purification methods like size-exclusion (MicroSpin G‑50 columns) or ion-exchange chromatography (Capto Q resin). High-quality reagents and proper buffers further enhance purity.

2. What technical support does Cytiva offer for oligonucleotide workflows?

Cytiva offers protocols, troubleshooting guides, and expert support for product selection, process optimization, and scale-up to GMP production.

3. What is the maximum oligonucleotide length supported by Cytiva purification products?

Most Cytiva columns and resins handle oligos up to 200 nucleotides or more. Check the product datasheet for exact compatibility.