Sartorius Chromatography Membrane & Sanitary Adapter

Sartorius AG, founded in 1870 in Göttingen, Germany, is a global life-science supplier focused on bioprocess solutions, lab supplies, and services.

This page is about chromatography consumables media. As one of the most trustworthy distributors of Sartorius, iRight offers you the most competitive price and the best quality. Please contact us for detailed pricing, packing, and shipping information.

Sartorius Sartobind® S 150 mL Capsule

Sartorius Sartobind^® S membrane adsorber units combine the advantages of convective media and ion exchange chromatography for rapid and easy contaminant removal or capture of virus and virus-like particles.

For item No. 96IEXS42E9BFF,Iright sells it in a pre-packed single-use capsule (150 mL bed) with ¾″ sanitary tri-clamp in/out. The Sartobind S 150ml Capsule is mainly used in the removal of host-cell protein & DNA in mAb polishing, aggregate removal, and high-capacity capture or polishing of viruses/VLPs.

Key Parameters

• Membrane/Ligand: > 3 µm macroporous, stabilized cellulose membrane functionalised with sulfonic-acid groups (strong cation exchanger).
• Bed Volume & Height: 150 mL with an 8 mm bed height; approximate adsorptive surface area ≈ 5,500 cm². Can be operated at 0.75 L min⁻¹ (≈ 30 column volumes min⁻¹).
• Connection: ¾″ Tri-Clamp (25 mm) sanitary quick-fit; polypropylene housing, weight ≈ 400 g; maximum operating pressure 4 bar (0.4 MPa / 58 psi).
• pH & Chemical Stability: Short-term pH 3–14 / long-term pH 4–13; compatible with common chromatography buffers; avoid peroxides.
• Dynamic Binding Capacity (Lysozyme, 10 % BT): ≈ 25 mg mL⁻¹ → each capsule can adsorb ≈ 3.9 g of protein.

Process Advantages

• High Linear Velocity, Low ΔP: Maintains a pressure drop < 3 bar even at flow rates > 30 bed volumes min⁻¹, shrinking the chromatography step from hours to mere minutes.
• Macro-Molecule/Virus Friendly: Binding capacity for viruses and VLPs is > 10 × that of conventional resins; during antibody polishing, HCP/DNA clearance can reach up to 200 × higher.
• Single-Use Plug-and-Play: No column packing or cleaning validation required. Capsules are gamma-irradiated, ready-to-use, and fully compliant with cGMP single-use workflows.
• Low Buffer Use: An optimised void volume of just 0.2 L (≈ 1.3 MV) saves > 40 % buffer compared with non-optimised capsules.
• Re-usable: For non-viral polishing, the capsule has been validated for 3–5 cleaning cycles with 0.1 M NaOH, further reducing cost of goods (COG).

Application Examples

• mAb Flow-Through Polishing: Deployed downstream of the Protein A capture and primary CEX steps; removes residual HCP, DNA and aggregates within 2–3 column volumes at linear velocities of 10–30 BV min⁻¹.
• AAV/Adenovirus Capture & Concentration: Operated in bind–elute mode to boost viral titre and shorten pre-inactivation processing time; already implemented in commercial gene-therapy manufacturing.
• Emergency Aggregate Filtration: When a sudden aggregate spike arises post-UF/DF, the capsule can be clamped in-line as a 30-second “guard column”, preventing an entire batch from going out of specification.
• Linear Scale-Up to 5 L Jumbo: 0.08 mL Pico → 3 mL Nano → 150 mL Capsule → 5 L Jumbo formats, all sharing the same ligand chemistry and 8 mm bed height for seamless process transfer.

25 mm Sanitary-to-UNF 10-32 Adapter

The Sartorius Sanitary Adapter converts the small UNF 10-32 female outlet on mini/analytical Sartobind devices to a hygienic ½″–¾″ sanitary clamp, matching standard bioprocess tubing manifolds. 

Iright sells Sanitary Adapters 1ZAOGV0003 at reasonable prices with premium quality. You can email us for detailed pricing information.

Spec & Material

Application Examples

• Lab-to-GMP Closed-Loop Transition: Seamlessly integrates Pico/Nano capsules into production-scale ¾″ Tri-Clamp flow paths with no change of fittings, streamlining tech transfer.
• Rapid Connect/Disconnect for Single-Use Systems: After co-sterilisation with the capsule, the adapter can be installed or removed in under one minute, enabling emergency aggregate capture, rapid screening, and other short-duration operations.
• Validation & Compliance: The POM body is supported by complete biocompatibility documentation; used with an EPDM gasket and ISO-2852 clamp, it can be incorporated directly into the validation package.
• Minimised Leakage & Dead Volume: Replaces improvised luer-lock adapters, maintains a ¾″ sanitary seal, and eliminates micro-dead volumes—ensuring the virus-clearance step remains a true closed system.