Sartorius Tangential Flow Filtration (TFF) Solutions
Tangential Flow Filtration (TFF) is an essential separation technique extensively utilized in biopharmaceutical and biotech processes for concentrating, diafiltering, and purifying biomolecules. Unlike traditional filtration methods, TFF continuously passes the feed stream parallel to the membrane surface, significantly reducing membrane fouling and enhancing process efficiency.
Sartorius, a global leader in filtration technology, offers advanced TFF solutions tailored to meet the rigorous demands of laboratory, pilot-scale, and production-scale applications. Sartorius’s innovative products, such as Sartocon® Slice and Sartocon® Slice Cassette, provide reliable, scalable, and high-performance filtration, making them indispensable tools in modern bioprocessing operations.
Contact Iright now for detailed Sartorius TFF Filter products pricing.
Sartocon® Cassette
Sartocon® cassettes are designed with self-sealing features, minimal extractables, and enlarged feed and retentate ports to reduce system pressure drops. These cassettes are ideally integrated with Sartorius Sartocon holders and systems for optimized performance.
Hydrosart® Membrane
Sartocon® Hydrosart® cassettes are distinguished by their ultra-low protein adsorption, straightforward cleaning procedures, increased yield, and extended product lifespan. The Hydrosart® ultrafiltration membrane consistently maintains high performance with minimal fouling or loss of retention, even with repeated use.
Hydrosart® is a stabilized cellulose-based, high-performance membrane specifically optimized for biopharmaceutical processing applications. It is highly stable across a wide pH range, exceptionally hydrophilic, which reduces protein binding, and demonstrates virtually no fouling. Membrane depyrogenation can be efficiently performed using NaOH, even at high temperatures, making Hydrosart® particularly suited for biological processes.
Available Cut-Offs:
E-screen: 2 | 5 | 10 | 30 | 100 | 300 kDa
ECO screen: 10 | 30 | 100 | 300 kDa
| Name | Item No. | Filtration Area | Flow Channel Geometry | pH Stability |
| Sartocon® Cassette | Hydrosart® | 10kDa | 0.6m² | E-Screen | 3021443906E--SW | 0.6 m² | Protein conc. >20% /or viscosity above.3cp | pH 2 – 14 |
| Sartocon® Cassette | Hydrosart® | 30kDa | 0.6m² | E-Screen | 3021445906E--SW | 0.6 m² | Protein conc. >20% /or viscosity above.3cp | pH 2 – 14 |
| Sartocon® Slice Cassette | Hydrosart® | 10kDa | 0.1m² | E-Screen | 3051443901E--SW | 0.1 m² | Protein conc. >20% /or viscosity above.3cp | pH 2 – 14 |
| Sartocon® Slice Cassette | Hydrosart® | 10kDa | 0.14m² | ECO Screen | 3M51443901E--SW | 0.14 m² | Protein conc. <20% /or viscosity max.3cp | pH 2 – 14 |
| Sartocon® Slice Cassette | Hydrosart® | 30kDa | 0.14m² | ECO Screen | 3M51445901E--SW | 0.14 m² | Protein conc. <20% /or viscosity max.3cp | pH 2 – 14 |
| Sartocube® Cassette | Hydrosart® | 30kDa | 3m² | E-Screen | 3021445930E-BSW | 3 m² | Protein conc. >20% /or viscosity above.3cp | pH 2 – 14 |
Polyethersulfone (PES) Membrane
Polyethersulfone (PES) membranes are widely established in biopharmaceutical applications due to their robust polymer composition, providing excellent stability across diverse pH and temperature conditions and resilience to rigorous cleaning protocols.
Sartocon® Polyethersulfone TFF cassettes are extensively utilized in the biotechnology and pharmaceutical industries, offering stability over a broad operational range. PES membranes can be effectively regenerated, stored, and depyrogenated using NaOH, even at elevated temperatures.
Available Cut-Offs:
E-screen: 1 | 5 | 8 | 10 | Albumin | 30 | 50 | 100 | 300 kDa
ECO screen: 10 | 30 | 100 | 300 kDa
Flow Channel Geometry
The Sartocon® product line offers two distinct flow channel geometries. E-Screen filters are predominantly applied for protein concentrations exceeding 20% and viscosities higher than 3 cp. ECO-Screen filters are optimal for economical filtration of aqueous protein solutions below 20% concentration and viscosities under 3 cp.
Available Sizes
Sartorius Sartocon® and Sartocube® TFF cassettes come in various sizes suitable for pilot-scale and production-scale operations. Additionally, Sartocon® Slice and Sartocon® Slice 200 formats are designed for handling reduced sample volumes efficiently.
| Name | Item No. | Filtration Area | Flow Channel Geometry | pH Stability |
| Sartocon® Slice Cassette | PES | 30kDa | 0.1m² | E-Screen | 3051465901E--SW | 0.1 m² | Protein conc. >20% /or viscosity above.3cp | pH 1 – 14 |
| Sartocon® Slice Cassette | PES | Albumin | 0.1m² | E-Screen | 305146AL01K--SW | 0.1 m² | Protein conc. >20% /or viscosity above.3cp | pH 1 – 14 |
| Sartocon® Slice Cassette | PES | 30kDa | 0.14m² | ECO Screen | 3M51465901E--SW | 0.14 m² | Protein conc. <20% /or viscosity max.3cp | pH 1 – 14 |
| Sartocon® Slice Cassette | PES | 100kDa | 0.14m² | ECO Screen | 3M51466801E--SW | 0.14 m² | Protein conc. <20% /or viscosity max.3cp | pH 1 – 14 |
Regulatory Compliance
All materials in direct contact with products comply with the latest USP Biological and Cytotoxicity Tests. Furthermore, these materials are certified free from BSE and TSE. The filtrate quality meets or surpasses current USP and EP standards for sterile Water for Injection concerning extractable substances, oxidizable substances, and bacterial endotoxins.