Sartorius Process Analytical Technology (PAT) & Umetrics Software

If you’re scaling cell culture or fermentation, you need tight, real-time control of what’s happening inside your bioreactor—and you need it to work from small-scale development to GMP manufacturing. The Sartorius BioPAT® sensor family, together with Biobrain® Supervise (formerly BioPAT® MFCS) and the Umetrics® Suite (SIMCA®, SIMCA®-online, MODDE®), gives you that visibility and control across single-use and multi-use platforms. This Collection curates the most relevant Sartorius PAT hardware and analytics so you can quickly compare options, shortlist the right components, and move confidently toward implementation.

What Is PAT & Why It Matters (in Bioprocessing)

Process Analytical Technology (PAT) is the practice of measuring critical quality attributes and process parameters in real time and using those insights to control the process. In practical terms, PAT helps you shorten development cycles, improve batch consistency, and support QbD-driven tech transfer. Sartorius enables this with in-situ sensors—biomass, turbidity/OD, off-gas, flow, UV, Raman—and software that contextualizes data and automates control actions across Ambr® and Biostat® systems.

Use Cases & Target Workflows

Below are common, high-impact scenarios where Sartorius PAT + analytics shine. Skim, then jump to the Monitoring Map or Selection Guide to choose parts.

• Intensified perfusion & seed trains — Combine VCD control (BioPAT® Viamass) with single-use flow and pressure sensing to stabilize cell density and media exchange. Use SIMCA-online to watch multivariate health in real time.
  
• Scale-down modeling in Ambr® — Add BioPAT® Spectro Raman to Ambr® 15/250 to model glucose/lactate trends and build MVDA models in SIMCA; later deploy to SIMCA-online.
  
• Microbial fermentation control — Track OUR/CPR with BioPAT® Xgas and OD/turbidity with BioPAT® Fundalux to optimize feeds and induction timing.
  
• Chromatography & in-line concentration — Use BioPAT® Spectro UV for single-use, in-line UV absorbance, and feed the results to Biobrain® Supervise and SIMCA-Q for smarter pooling rules.
  
• GMP manufacturing oversight — Centralize data and recipe control in Biobrain® Supervise (OPC UA connectivity), plus alarms and deviation detection in SIMCA-online.

Monitoring Map: Parameters ↔ Recommended Sensor / Software

To speed selection, use this quick cross-reference. It’s organized by what you want to monitor first.

Selection Guide: How to Choose (Fast)

Choosing PAT is easier if you start from the decision you need to make.

1. What are you trying to control or decide?

   • Feed / perfusion rate: Pair BioPAT® Viamass for VCD-driven control with BioPAT® Flow for accurate single-use flow feedback.

   • Induction / harvest timing: Use BioPAT® Xgas (OUR/CPR trends) and Fundalux (OD/turbidity).

   • Pooling rules / concentration targets: Add BioPAT® Spectro UV inline, and monitor trends in SIMCA-online.

2. Where will you deploy?

   • Ambr® scale-down: Choose BioPAT® Spectro options for Ambr® 15/250; export SIMCA-ready files for model building.

   • Biostat STR® (SU manufacturing): Integrate Viamass SU sensors, Xgas off-gas, Spectro UV, Flow; orchestrate with Biobrain® Supervise.

3. What analytics do you need today vs. tomorrow?

   • Design & optimize: MODDE® for DOE; SIMCA® to interpret multivariate data and build robust models.

   • Run & release: SIMCA®-online for real-time trending, alarms, and predictions; link to Biobrain® recipes for closed-loop control.

Featured Models & Specifications (Selected SKUs)

The SKUs below match the official Sartorius eShop. Use them in RFQs or internal BOMs.

Software & Analytics (SIMCA / SIMCA-online / MODDE)

To turn sensor signals into decisions, you’ll likely combine design tools, modelers, and a runtime engine:

• MODDE® — Design experiments, explore factor space, and define robust operating ranges with intuitive DOE workflows. Ideal for building your first PAT strategy and deciding what to measure, when, and at which scale.
  
• SIMCA® — Build MVDA models from Ambr®/Biostat® runs, Raman spectra, UV traces, and historical batches; visualize clusters and trends, and export validated models for production.
  
• SIMCA®-online — Deploy those models at line-speed to watch evolving batch trajectories, set alarms and emails, and predict endpoints—all visible from thin clients and web dashboards.
  

All three options are available from the Sartorius eShop with SKUs above, and Biobrain® Supervise provides native connectivity to SIMCA/SIMCA-online for closed-loop control when required.

FAQs

Q1: How does BioPAT® Viamass differ from offline cell counts?

Viamass measures viable biomass in situ using impedance (capacitance) and feeds a continuous signal to your controller; it reduces manual sampling and enables real-time control strategies in single-use and multi-use reactors.

Q2: What off-gas ranges can BioPAT® Xgas measure?

O₂ from 1–50 % vol and CO₂ from 0–10 % vol, with automatic compensation for humidity and pressure; OUR/CPR/RQ are computed in the supervisory software.

Q3: Can Raman (BioPAT® Spectro) be used in Ambr®?

Yes. Sartorius offers Spectro options for Ambr® 15 and Ambr® 250 analysis modules; data export is SIMCA-ready for model building and transfer.

Q4: Do I need separate licenses for runtime monitoring?

Yes—SIMCA® (modeling) and SIMCA®-online (runtime) are licensed separately; SIMCA-online is licensed on the server and clients need no license. 

Conclusion

Ready to configure a sensor + software stack for your line? Contact Iright for model selection help, lead times, and a formal quotation using the exact SKUs above. Our team can also map your current equipment to Biobrain® Supervise and set up a SIMCA®/SIMCA-online trial project so you can see the benefit on your own data.