Agilent, 761775-902, ZORBAX Extend 300 C18, 2.1 x 100 mm, 3.5 µm

ZORBAX Extend 300 C18, 2.1 x 100 mm, 3.5 µm. A reversed-phase C18 HPLC column with fully porous ZORBAX particles. The 300-Extend C18 chemistry incorporates a unique bidentate silane which allows the column to withstand pH up to 11.5.

Specifications:
Brand: ZORBAX
Hardware: SS
Inner Diameter (ID): 2.1 mm
LC Platform: Stainless Steel
Length: 100 mm
Maximum Temperature: 40 °C at pH 8-11.560 °C at pH 6-8
Part Number Application Domain: Biopharma
Part Number Application: Monoclonal Antibodies (mABs)PeptidesProteins
Particle Size: 3.5 µm
Particle Type: Fully Porous
Phase: Extend-C18
Pore Size: 300 Å
Pressure Rating: 400 bar
Separation Mode: Reversed Phase
Shipping Solvent: Acetonitrile/Water
Technique: LCLC & LC/MS
UNSPSC Code: 41115709
pH Range: 2-11

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The ZORBAX Extend 300 C18 column features a 2.1 mm internal diameter, 100 mm length, and 3.5 micron particle size, optimized for advanced reversed-phase liquid chromatography separations. Engineered with an innovative bidentate C18 bonding technology, it delivers extended pH stability from 2 to 11, enabling robust analyses of peptides, proteins, and small molecules under a wide range of mobile phase conditions. The large 300 angstrom pore size enhances performance for biomolecular separations, such as intact proteins, monoclonal antibodies, and peptide mapping workflows.

This column is ideal for pharmaceutical, biotechnology, and proteomics laboratories seeking reproducible results in method development, stability testing, or complex sample profiling. Typical usage scenarios include characterization of bio-therapeutics, peptide quantification, and compatibility with both acidic and basic mobile phases. It supports high-efficiency separations with sharp peak shapes even for large molecular weight analytes.

Fully compatible with Agilent 1100, 1200, and 1290 Series LC systems and other HPLC and UHPLC instruments, this column integrates seamlessly into existing chromatographic workflows. It is also compatible with a wide selection of ZORBAX guard columns and sample preparation solutions, offering comprehensive support for demanding research and analytical applications.