Agilent, 783775-906, AdvanceBio RP-mAb SB-C8, 2.1 x 150 mm, 3.5 µm

AdvanceBio RP-mAb SB-C8, 2.1 x 150 mm, 3.5 µm. A reversed-phase C8 HPLC column with superficially porous particles and a wide (450 Å) pore size designed for intact or subunit analysis of mAbs. StableBond technology ensures stability at low pH.

Specifications:
Brand: AdvanceBio RP mAb C8
Hardware: SS
Inner Diameter (ID): 2.1 mm
LC Platform: Stainless Steel
Length: 150 mm
Maximum Temperature: 90 °C
Part Number Application Domain: Biopharma
Part Number Application: Intact & Subunit AnalysisMonoclonal Antibodies (mABs)Proteins
Particle Size: 3.5 µm
Particle Type: Superficially Porous
Phase: SB-C8
Pore Size: 450 Å
Pressure Rating: 600 bar
Separation Mode: Reversed Phase
Shipping Solvent: Acetonitrile/Water
Technique: LCLC & LC/MS
UNSPSC Code: 41115711
pH Range: 1-8

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This high-performance reversed-phase column is engineered for robust and reliable characterization of monoclonal antibodies and related biologics. Featuring a 2.1 x 150 mm format with 3.5 micron stable-bond C8 particles, it provides optimized selectivity and resolution for intact proteins, antibody fragments, and peptides. Its advanced surface technology ensures excellent peak shapes, high recovery, and minimized carryover, supporting both qualitative and quantitative analyses in biopharmaceutical research and quality control environments.

Designed for compatibility with ultra-high-performance liquid chromatography systems, this column offers excellent reproducibility and durability under challenging gradient conditions commonly used for mAb variant analysis. It is particularly suitable for applications such as purity assessment, aggregate characterization, and monitoring post-translational modifications. Its reliable performance and efficiency make it ideal for method development, lot release, and comparability studies.

The column seamlessly integrates with Agilent liquid chromatography platforms, including 1200 Infinity and 1260 Infinity II series, and can be used with a wide range of detection methods such as UV and mass spectrometry. For extended analytical workflows, it complements other AdvanceBio columns targeting size exclusion, ion exchange, and hydrophobic interaction chromatography to provide comprehensive biomolecule characterization.