Agilent, 789975-906, AdvanceBio RP-mAb SB-C8, 4.6 x 50 mm, 3.5 µm

AdvanceBio RP-mAb SB-C8, 4.6 x 50 mm, 3.5 µm. A reversed-phase C8 HPLC column with superficially porous particles and a wide (450 Å) pore size designed for intact or subunit analysis of mAbs. StableBond technology ensures stability at low pH.

Specifications:
Brand: AdvanceBio RP mAb C8
Hardware: SS
Inner Diameter (ID): 4.6 mm
LC Platform: Stainless Steel
Length: 50 mm
Maximum Temperature: 90 °C
Part Number Application Domain: Biopharma
Part Number Application: Intact & Subunit AnalysisMonoclonal Antibodies (mABs)Proteins
Particle Size: 3.5 µm
Particle Type: Superficially Porous
Phase: SB-C8
Pore Size: 450 Å
Pressure Rating: 600 bar
Separation Mode: Reversed Phase
Shipping Solvent: Acetonitrile/Water
Technique: LCLC & LC/MS
UNSPSC Code: 41115711
pH Range: 1-8

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The AdvanceBio RP-mAb SB-C8, 4.6 x 50 mm, 3.5 µm column is engineered for high-resolution reversed-phase liquid chromatography of monoclonal antibodies and related biotherapeutic proteins. Designed with a stable silica-based C8 bonded phase, this column offers optimal selectivity for intact proteins, antibody subunits, and fragments. Its 3.5-micrometer particle size delivers fast separations with sharp peak shapes and reliable reproducibility, making it ideal for both method development and routine analytical workflows in biopharmaceutical research.

This robust column supports critical quality attribute analysis, including purity, aggregation, and degradation assessment, and is well-suited for use in drug development and quality control laboratories. Compatible with high and ultrahigh-performance liquid chromatography systems, it integrates seamlessly with Agilent 1200 Infinity and 1260 Infinity II series, as well as other major LC platforms. Pairing with Agilent AdvanceBio buffers and sample preparation kits further enhances analytical performance and reproducibility.

Typical users include researchers focused on antibody therapeutics, biosimilar characterization, or process monitoring. The column's efficient format and high stability under commonly used reversed-phase conditions ensure consistent results and prolonged column lifetime, supporting rigorous analytical demands in regulated and research environments.