Agilent, 795975-944, AdvanceBio RP-mAb Diphenyl, 4.6 x 100 mm, 3.5 µm

AdvanceBio RP-mAb Diphenyl, 4.6 x 100 mm, 3.5 µm. A reversed-phase diphenyl HPLC column with superficially porous particles and a wide (450 Å) pore size designed for mAbs and other larger proteins when alternate selectivity is needed or preferred.

Specifications:
Brand: AdvanceBio RP mAb Diphenyl
Hardware: SS
Inner Diameter (ID): 4.6 mm
LC Platform: Stainless Steel
Length: 100 mm
Maximum Temperature: 90 °C
Part Number Application Domain: Biopharma
Part Number Application: Intact & Subunit AnalysisMonoclonal Antibodies (mABs)Proteins
Particle Size: 3.5 µm
Particle Type: Superficially Porous
Phase: Diphenyl
Pore Size: 450 Å
Pressure Rating: 600 bar
Separation Mode: Reversed Phase
Shipping Solvent: Acetonitrile/Water
Technique: LCLC & LC/MS
UNSPSC Code: 41115711
pH Range: 1-8

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The AdvanceBio RP-mAb Diphenyl column is designed for high-performance reversed-phase chromatography of monoclonal antibodies and related biotherapeutics. With dimensions of 4.6 x 100 mm and a 3.5 micron particle size, this column delivers efficient protein and peptide separations, enabling detailed characterization of primary structures and post-translational modifications. Its proprietary diphenyl stationary phase ensures optimal selectivity and resolution, particularly suited for complex samples such as intact mAbs, antibody fragments, or subunits. The column is engineered for excellent reproducibility and durability, making it ideal for method development, quality control, or in-depth biopharmaceutical research.

Typical applications include therapeutic antibody purity assessment, peptide mapping, glycoprofiling, and aggregate analysis. The column is fully compatible with most HPLC and UHPLC systems, including Agilent 1260 Infinity and 1290 Infinity LC platforms, as well as other leading chromatography instruments. It can be seamlessly integrated with advanced detection techniques, such as UV and mass spectrometry, to meet a variety of analytical workflows. For enhanced analytical performance, the column is complemented by Agilent’s family of AdvanceBio columns and biopharma consumables, supporting comprehensive biomolecule analysis from discovery to production quality assurance.