Agilent, PL1580-3201, AdvanceBio SEC 200 Å, 4.6 x 150 mm, 1.9 µm, LC column

AdvanceBio SEC 200 Å, 4.6 x 150 mm, 1.9 µm, LC column. A size exclusion column designed to improve resolution and provide faster separation of monoclonal antibody aggregates and fragments by UHPLC. The resolving range is 2-700 kDa.

Specifications:
Brand: AdvanceBio SEC
Guard Column: No
Hardware: SS
Inner Diameter (ID): 4.6 mm
LC Platform: Stainless Steel
Length: 150 mm
Maximum Temperature: 80 °C (20 to 40 °C recommended)
Molecular Weight Lower Limit: 2000 Da
Molecular Weight Upper Limit: 700000 Da
Particle Size: 1.9 µm
Phase: SEC
Pore Size: 200 Å
Pressure Rating: 620 bar
Separation Mode: Size Exclusion (SEC)
Shipping Solvent: Phosphate Buffer/0.02% Sodium azide
UNSPSC Code: 41115709
pH Range: 2-8.5

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Designed for high-resolution size exclusion chromatography, this silica-based LC column features a 200 angstrom pore size, 4.6 x 150 mm dimensions, and 1.9 micron particle size. It is expertly engineered for the fast and accurate characterization of biomolecules such as monoclonal antibodies, ADCs, and other therapeutic proteins. Its advanced particle technology delivers superior resolution, sharp peak shapes, and low carryover, making it ideal for high-throughput laboratories and researchers focused on molecular size distribution, aggregation analysis, and purity assessment.

This column operates efficiently at high flow rates and is fully compatible with UHPLC and HPLC systems, including Agilent 1260 Infinity, 1290 Infinity II, and comparable models from other major manufacturers. It is also suitable for use with a wide range of mobile phases commonly used in biopharmaceutical analysis. Pairing seamlessly with AdvanceBio SEC guard columns and Agilent biomolecule workflow solutions, it enables consistent, reproducible results in both regulated and R&D environments. The robust design ensures chemical stability and long column lifetime, supporting the rigorous demands of protein characterization and QC laboratories. This column is an optimal choice for researchers seeking performance, reliability, and compatibility in SEC applications.