Cytiva, CB0022L11-21, Cellbag™ Bioreactor Containers with Bioclear™ 11 Film

Cellbag BioClear 11, BC11, DO, RM Cellbag™ bioreactor containers with Bioclear™ 11 film, a low antioxidant formulation with similar construction to Bioclear™ 10 film. Bioclear™ 11 film is recommended for cell lines that have been found to be sensitive to certain antioxidants. • Cellbag™ bioreactor containers are presterilized, disposable chambers for non-invasive mixing of fluids using a WAVE™ Bioreactor system. • Bioclear™ 11 film is a low antioxidant version of Bioclear™ 10 for use with CHO cells and other cell lines that have Irgafos™ antioxidant sensitivity. Cellbag™ bioreactor containers with Bioclear™ 11 film are made for use with WAVE™ Bioreactor systems. Cellbag™ bioreactor containers with Bioclear™ 11 are formulated for mammalian cell culture when degradation products of Irgafos 168 might interfere with growth of sensitive cell lines such as CHO cells. Cellbag™ bioreactor components are similar to those used for biological storage bags and meet USP Class VI specifications for plastics. A validation regulatory support guide is available to demonstrate biocompatibility. Cellbag™ bioreactor containers are available in many configurations. Volumes range from 2 to 200 L for use with WAVE™ rocking bioreactor systems. Cellbag™ bioreactor containers include air inlet and outlet filters, a needleless sampling port, and a fill/harvest port. In addition, each Cellbag™ bioreactor container can be customized with optional fittings such as ReadyMate aseptic connectors, dip tubes, an optical pH sensor embedded in the bag, screw cap ports, temperature ports, perfusion filters, and special tubing ports. Perfusion bioreactor applications Perfusion Cellbag™ bioreactor containers are fitted with a porous polyethylene–based lily pad filter that floats on the medium. This filter is used to retain cells in the bag during perfusion cultivation or medium exchange. Next generation Cellbag™ bioreactor film built specifically for bioprocessing Cellbag™ bioreactor containers with Fortem™ film are now available. Fortem™ was built from the ground up for biomanufacturing. Fortem™ film has supply chain security and is flexible yet strong enough for unit operations across the workflow, including mammalian cell culture in rocking bioreactors.